Author contributions
All individuals listed as authors met the ICMJE guidelines for determining authorship. AC, MV, DSS, DL and SS contributed to the conception and design of the study. AC, MV, MMF, RP, GV, CY, MJ, IC, JB, DL and SS screened patients and collected clinical data. SD and CP extracted biological data. AC and MV constituted the database, performed statistical analyses and wrote the first draft of the manuscript. SS made major revisions to the manuscript. SG provided her pharmacological expertise. DSS provided her expertise on histaminergic AE. DL provided his expertise on bradykinin-mediated AE. All authors read and approved the submitted version.