Introduction
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2
infection[1], was first identified in
Wuhan, China in January 2020 [2-4].
Since then, the number of patients with COVID-19 is dramatically
increasing all around the world[5-7].
Nucleic acid testing has played an important role in COVID-19 patient
diagnosis, isolation and discharge[8].
However, there is no available parameter can be used to accurately
determine when COVID-19 patients will test negative of SARS-CoV-2 after
effective treatments until now.
Compared with nucleic acid testing via nasopharyngeal swabs, Blood
routine detection is an easier and more convenient method. Dynamic
changes in routine blood parameters is not only helpful for COVID-19
diagnosis and typing, but also can discover the changes of patients’
condition and the emergence of complications in time, so as to better
judge the curative effect and guide the
treatment[9].
This study aims to explore feasible laboratory parameter which can be
used in clinical practice to estimate the time for SARS-CoV-2 nucleic
acid test results turning negative, so as to reduce nucleic acid test
frequency to avoid medical resource wastage and lower the infection risk
of medical staff.