Acknowledgement
We thank the funding support from the Science and technology research
project of Hubei Provincial Department of Education (D20202602), and the
Project of Hubei University of Arts and Science to Ke Wang (XK2019047
and 2020kypyfy030).
Address correspondence to: Dr. Juan Xiao, Hubei University of
Arts and Science, 38 Longzhong Road, Xiangcheng District, Xiangyang,
Hubei, 441053, China. Phone: 86-15007276400. Email: ju_126@126.com.
Declaration of conflict of interest: None.
Abstract: Until now, there are no parameter available for
guiding us the proper test scheme for COVID-19 patients during
hospitalization so that the physicians will learn their SARS-CoV-2
nucleic acid test results turning negative timely. This study aims to
explore feasible parameters to fulfill above requirements. We collected
clinical data from 69 patients (31 SARS-CoV-2 positive pneumonia, 38
SARS-CoV-2 negative pneumonia) in Xiangyang Central Hospital (Xiangyang,
China) from Feb 12 to Feb 18, 2020 in this study. The general and
laboratory data between two groups were compared and discrepant
parameters were used to assess the correlation with viral nucleic acid
test positive diagnosis. The sensitivity of these parameters to clinical
treatment and their correlation with the nucleic acidC t value were also analyzed. WBC, LYM% and PLT
decreased, while CRP and Hb increased significantly in SARS-CoV-2
positive patients compared to those in common pneumonia patients. LYM%,
Hb and WBC had a good predictive ability to distinguish the nucleic acid
positive from negative pneumonia. The dynamics of WBC, LYM%, Hb and CRP
in nucleic acid positive patients were more sensitive to clinical
treatment and gradually returned to normal level. Only LYM% had a
significant correlation with C t value. LYM%
dynamics was sensitive to clinical treatment, and significantly
correlated with C t value, and might be feasible
parameter to estimate the time for SARS-CoV-2 nucleic acid test results
turning negative.
Key words: SARS-CoV-2, COVID-19, LYM%,C t value