Introduction
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection[1], was first identified in Wuhan, China in January 2020 [2-4]. Since then, the number of patients with COVID-19 is dramatically increasing all around the world[5-7].
Nucleic acid testing has played an important role in COVID-19 patient diagnosis, isolation and discharge[8]. However, there is no available parameter can be used to accurately determine when COVID-19 patients will test negative of SARS-CoV-2 after effective treatments until now.
Compared with nucleic acid testing via nasopharyngeal swabs, Blood routine detection is an easier and more convenient method. Dynamic changes in routine blood parameters is not only helpful for COVID-19 diagnosis and typing, but also can discover the changes of patients’ condition and the emergence of complications in time, so as to better judge the curative effect and guide the treatment[9].
This study aims to explore feasible laboratory parameter which can be used in clinical practice to estimate the time for SARS-CoV-2 nucleic acid test results turning negative, so as to reduce nucleic acid test frequency to avoid medical resource wastage and lower the infection risk of medical staff.