Speckle Imaging Global Longitudinal Strain Data
Global longitudinal strain (GLS) was obtained with the Philips QLab TomTec AutoSTRAIN© software. We measured endocardial GLS from the apical 2-chamber, apical 3-chamber and apical 4-chamber views, to generate the global value. GLS, typically a negative percentage value as the deformation is a shortening dimension, was reported in absolute value throughout this manuscript. The autostrain measurement was first obtained, and then minor edits performed by the clinician were applied to better approximate the endocardial boarder and more accurately identify the mitral anulus. Two independent clinicians performed edited autostrain GLS measurements on 20 echocardiograms on two separate occasions to determine inter- and intra-rater reliability.