Association Analysis
The genotypes of lncRNA TDRG1 rs8506 were successfully evaluated
in the present study. As shown in Table 2, the distribution of the
genotypes agreed with the Hardy–Weinberg equilibrium in the healthy
controls (P = 0.234). We observed that the population who carried
rs8506 TT genotype had a 1.755-fold higher risk of sepsis than those did
not carry (TT vs . CC/CT: OR = 1.755, 95%CI = 1.028–2.996,P = 0.0394). Furthermore, after adjustments for age and gender,
significantly elevated risk of sepsis was also found in the rs8506 TT
genotype, as compared with rs8506 CC/CT genotype (TT vs . CC/CT:
adjusted OR = 1.751, 95%CI = 1.024–2.993, P = 0.0406).