References
1. Gupta S, Wang W, Hayek SS, et al. Association between early treatment
with tocilizumab and mortality among critically ill patients with
COVID-19. JAMA Intern Med 2020 October 20 (Epub ahead of print).
2. Rosas I, Bräu N, Waters M, et al. Tocilizumab in hospitalized
patients with COVID-19 pneumonia. September 12, 2020
(https://www.medrxiv.org/content/10.1101/2020.08.27.20183442v2. opens in
new tab). preprint.
3. Salvarani C, Dolci G, Massari M, et al. Effect of tocilizumab vs
standard care on clinical worsening in patients hospitalized with
COVID-19 pneumonia: a randomized clinical trial. JAMA Intern Med 2020
October 20 (Epub ahead of print).
4. Hermine O, Mariette X, Tharaux P-L, et al. Effect of tocilizumab vs
usual care in adults hospitalized with COVID-19 and moderate or severe
pneumonia: a randomized clinical trial. JAMA Intern Med 2020 October 20
(Epub ahead of print).
5. Stone JH, Frigault MJ, Serling-Boyd NJ, et al. Efficacy of
tocilizumab in patients hospitalized with Covid-19. N Engl J Med
2020;383:2333-2344.
6. Salama C, Han J, Yau L, et al. Tocilizumab in patients hospitalized
with Covid-19 pneumonia. N Engl J Med 2021;384:20-30. DOI:
10.1056/NEJMoa2030340
7. Ware LB. Physiological and biological heterogeneity in
COVID-19-associated acute respiratory distress syndrome. Lancet Respir
Med. 2020 Aug 27:S2213-2600(20)30369-6. doi:
10.1016/S2213-2600(20)30369-6. Epub ahead of print. PMID: 32861277.
8. Boregowda U, Perisetti A, Nanjappa A, Gajendran M, Kutti Sridharan G,
Goyal H. Addition of Tocilizumab to the Standard of Care Reduces
Mortality in Severe COVID-19: A Systematic Review and Meta-Analysis.
Front Med (Lausanne). 2020 Oct 2;7:586221. doi:
10.3389/fmed.2020.586221. PMID: 33123544; PMCID: PMC7566918.
9. Özdemir V, Endrenyi L. Toward Panvigilance for Medicinal Product
Regulation: Clinical Trial Design Using Extremely Discordant Biomarkers.
OMICS. 2019 Mar;23(3):131-133. doi: 10.1089/omi.2019.0013. Epub 2019 Feb
21. PMID: 30789303.
10. Şardaş S, Endrenyi L, Gürsoy UK, Hutz M, Lin B, Patrinos GP, Steuten
LM, Wang W, Warnich L, Özdemir V. A call for pharmacogenovigilance and
rapid falsification in the age of big data: why not first road test your
biomarker? OMICS. 2014 Nov;18(11):663-5. doi: 10.1089/omi.2014.0132.
Epub 2014 Oct 29. PMID: 25353263; PMCID: PMC4229703.