Analysis of repeated measurements
Linear Mixed Effects model: A Linear mixed effect model was built with sHLA-G as a function of gestational age with the group membership (SGA/AGA) as a fixed effect and participant ID as a random effect using lme4 package under the R statistical language and environment (www.r-project.org). The equation used was as follows: sHLA-G ~ time (in days) + Group + (time (in days) |Participant ID). Another model devoid of group membership (SGA/AGA) was constructed. The equation used was as follows: sHLA-G ~ time (in days) + (time (in days) |Participant ID). Both the models were compared using ANOVA function to evaluate whether being in SGA or AGA group was associated with variations in sHLA-G trajectories across pregnancy.