Figure Legends
Figure 1 . Representative orthogonal cross sections of
co-registered PET and MRI images
MRI, magnetic resonance imaging; PET, positron emission tomography; SUV,
standardised uptake value
Figure 2 : MR309 mean plasma–concentration time curves (PK
study)
Figure 3 . Representative time–activity curves and multilinear
analysis 1 method for selected regions of interest (PET study)
PET, positron emission tomography; ROI, region of interest; SUV,
standardised uptake value
A. PET baseline scan data; B. PET scan data, acquired ~2
hours after MR309 400 mg; C. PET scan data, acquired ~8
hours after MR309 400 mg
Figure 4: Brain σ1 receptor occupancy and plasma concentrations
of MR309 (PET study)
Dotted line represents a model fit to the data using
pharmacokinetic–σ-1 brain receptor Model 1 (Table 1). Vertical hashed
lines show the corresponding estimated EC50 and its 95%
confidence interval