Participant |
MR309 dose (mg/day) |
PET scan
time (hours post MR309 dose) |
[11C]SA-4503 VND
(mL/cm3) |
σ1 Receptor ΔBP (%) |
MR309 at start of PET scan (ng/mL) |
1 |
400 |
2 |
11.0 |
59.8 |
2280 |
|
|
8 |
|
46.1 |
750 |
2 |
400 |
2 |
23.2 |
73.8 |
1630 |
|
|
8 |
|
52.0 |
946 |
3 |
200 |
2 |
15.0 |
30.5 |
1640 |
|
|
8 |
|
30.7 |
457 |
4 |
200 |
2 |
11.8 |
48.3 |
2720 |
|
|
8 |
|
46.7 |
1270 |
5 |
800 |
2 |
16.8 |
74.9 |
3780 |
|
|
8 |
|
36.6 |
1320 |
6 |
800 |
2 |
20.0 |
64.9 |
4410 |
|
|
8 |
|
32.7 |
1360 |
7 |
200 |
2 |
22.9 |
55.1 |
999 |
|
|
8 |
|
55.5 |
289 |