Participant MR309 dose (mg/day) PET scan time (hours post MR309 dose) [11C]SA-4503 VND (mL/cm3) σ1 Receptor ΔBP (%) MR309 at start of PET scan (ng/mL)
1 400 2 11.0 59.8 2280
8 46.1 750
2 400 2 23.2 73.8 1630
8 52.0 946
3 200 2 15.0 30.5 1640
8 30.7 457
4 200 2 11.8 48.3 2720
8 46.7 1270
5 800 2 16.8 74.9 3780
8 36.6 1320
6 800 2 20.0 64.9 4410
8 32.7 1360
7 200 2 22.9 55.1 999
8 55.5 289