MR309 200 mg BID
(N=16) MR309 400 mg QD
(N=16)
AUCtau (ng.h/mL) AUCtau (ng.h/mL) AUCtau (ng.h/mL)
Geometric mean (log SD)
31279 (0.2)
58412 (0.2)
CV (%)
23.9
20.9
Arithmetic mean (SD)
32113 (7744)
59572 (12097)
Median (min, max)
33378 (20631, 52275)
60822 (39532)
Cmaxss (ng/mL) Cmaxss (ng/mL) Cmaxss (ng/mL)
Geometric mean (log SD)
4143 (0.2)
5222 (0.2)
CV (%)
17.2
18.3
Arithmetic mean (SD)
4200 (719)
5304 (969)
Median (min, max)
4395 (3010, 5940)
5300 (3920, 7140)
Cminss (ng/mL) Cminss (ng/mL) Cminss (ng/mL)
Geometric mean (log SD)
1915 (0.3)
1764 (0.3)
CV (%)
29.8
29.9
Arithmetic mean (SD)
1991 (580)
1832 (493)
Median (min, max)
2055 (1070, 3510)
1870 (856, 2860)
tmaxss (h) tmaxss (h) tmaxss (h)
Arithmetic mean (SD)
1.28 (0.47)
1.40 (0.38)
Median (min, max)
1.00 (0.67, 2.33)
1.33 (0.63, 2.0)
Fluctuation (%)a Fluctuation (%)a Fluctuation (%)a
Arithmetic mean (SD)
86 (22)
145 (49)