Mann Whitney U test with p value: 0.017
67 DBPCFC were performed for all patients with non - IgE mediated CMPA, resulting in 58/67 (86%) positivity. In IgE - mediated CMPA, DBPCFC was not performed since they completed diagnostic criteria with the clinical picture and laboratory tests. At the moment of CMPA diagnosis 51 patients were using nutritional replacement formulas.19 (37.5%) were using casein hydrolysate formulas, 17 (33.3%) partially hydrolyzed rice formulas, 11 (20.9%) elemental amino acid formulas, and 4 (8.3%) soy formulas. After 1 year of follow up, a median of 104 mg/dL was obtained in the FC test with an IQR of 72-136 and a median of 620 mg/dL in the EDN with an IQR of 406 – 1316; the median differences in FC 1 year after diagnosis had significant p value < 0.0001 while with EDN no significant differences were found. 52/64 (81%) patients after 1 year acquired tolerance to cow’s milk proteins after undergoing DBPCFC. 33 patients used nutritional replacement formulas during the 1 year of follow up at least 3 times a week, 16 patients used the hypoallergenic Nutramigen LGG formula, of which 15 (94%) acquired tolerance to cow’s milk proteins 1 year after undergoing DBPCFC. 17 used other formulas of which 12 (71%) acquired tolerance (p 0.08) (graph 5). Between both groups, it was found that after 1 year the patients who used Nutramigen LGG reduced their FC values with a median of 89 mg/dL and an IQR of 65-112 (p: 0.12). 1/2 (50%), 4/6 (66%), 7/9 (78%) of those using soy formula, AA Formula (Puramino), and Partially Hydrolyzed Rice Formula developed tolerance to milk proteins of cow after 1 year respectively. The patients who used nutritional replacement formulas did not describe allergic or infectious adverse events or serious adverse events related to the consumption of the formulas. Malnutrition after one year was reduced to 11/64 (17.18%)
Graph 5 . Acquisition of tolerance to CMP after one year of diagnosis