Statistical analysis
After data collection and coding, statistical analysis was performed
using GraphPad Prism 9(The authors confirm that they had obtained
copyright licenses). Descriptive analysis was performed on all
variables for which the data were frequency and percentage
distributions, including demographic data and clinical characteristics.
The mean and standard deviation (SD) for the measurement data was
calculated. When comparing the mean of the samples of the two groups in
the measurement data, the Unpaired t-test was used for the comparison of
groups with normal distribution, and the Mann-Whitney test was used for
the comparison of groups with no normal distribution. When comparing the
mean of the three groups of samples in the measurement data, a
pair-to-pair comparison was conducted among the three groups. A
parametric test (ANOVA test) was used for comparison between groups that
all obeyed normal distribution, and a non-parametric test
(Kruskal-Wallis test) was used for comparison between groups that did
not obey normal distribution. When analyzing the correlation of
laboratory indicators, the Pearson correlation coefficient is used to
calculate the bivariate correlation if both variables obey the normal
distribution, and the Spearman correlation coefficient is used to
calculate the bivariate correlation if some variables do not obey the
normal distribution. The difference was statistically significant with
P<0.05.