Acknowledgments
This work was supported by the National Natural Science Foundation of China (Grant numbers 81760332), the Tibet Natural Science Foundation (Grant numbers XZ202101ZR0100G), the Research Found for Advanced Talents of Xizang Minzu University (Grant numbers RCYJ602111), National Natural Science Foundation of China, Medical School of Xizang University for Nationalities (Grant numbers XZMZ-M2022N02), National University Students Innovation Research Project (Grant numbers 202010695029 and 202110695033)and Graduate research innovation and Practice project of Xizang Minzu University(Grant numbers Y2022097). Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region ( Grant numbers KF2022008).