Study population
The confirmed Covid-19 infected inpatients with mild to severe disease were enrolled in the study, according to their clinical symptoms with a positive diagnostic kit result (RT-PCR) or typical radiologic changes at chest computed tomograph (CT) (Fang et al., 2020), with the approval of the specialist in this hospital for Covid-19 diagnosis, and clinically requirement of hospitalization(Iranian Ministry of health and Medical Education , 28 Feb 2020).
The patient’s medical informations including demographic data, clinical features, the result of Covid-19 test (PCR), chest CT scans, comorbidities and underling disease (hypertention, diabete, pulmonary disease, cardiovascular and kidney disease), the admission to the intensive care unit (ICU), the requirement of mechanical ventilation, the duration of hospitalization, their outcome and mortality, extracted from hospital documented patient’s data recorded in this hospital.
Patients with a history of allergic reactions or known contraindications (QT-prolongation) or drug interactions with routine regimens, or lack of data in their documents, and the patients who die within the first 24 hours of hospitalization, exclude from study.
Patients in this study were enrolled by simple random sampling without stratification.
This study was conducted in accordance with the declaration of Helsinki and was approved by the Ethics committee of Tehran University of Medical Science (Ethic number : IR.TUMS.MEDICINE.REC.1399.396 ) .
Written informed consent was obtained from all patients when admitted to the hospital. patients confidentiality was considered by protecting their data and documents.