3.5 Effects of empagliflozin on IL-1β-induced NF-κB pathway
activation in mouse chondrocytes
To explore the underlying mechanism, the effects of empagliflozin on
NF-κB pathway activation were investigated. As illustrated in Figure 5,
empagliflozin activated the NF-κB pathway in mouse chondrocytes
represented as higher levels of the activated status of P65
(phosphor-P65, p-P65) and IκB (phosphor-IκB, p-IκB). The above
IL-1β-induced NF-κB pathway activation was inhibited by empagliflozin
pretreatment. The results indicated that empagliflozin could inhibit
IL-1β-induced NF-κB pathway activation in mouse chondrocytes.