DEG identification, KEGG and GO Enrichment
As displayed in heat map Fig S1 , there are 108 DEGs in the heat map. KEGG and GO enrichment of DEGs were fabricated using DAVID online database. As Fig1 (A,B,C)shows, GO consisted of biological process (BP), cellular components (CC), molecular functions (MF). BP analysis of DEGs mainly shows signal transduction, positive regulation of inflammatory response and chemokine production. For CC terms, DEGs were enriched mainly in cytoplasm, membrane, and cytosol; while in protein binding, protein kinase binding, Calcium ion binding and collagen binding for MF. KEGG pathway shows the enrichment of DEGs mainly in cytokine-cytokine receptor, JAK-STAT signaling pathway and cAMP signaling pathway (Fig1 D ).