Conclusion
Among the NR4a1 mediated several pathways, NFκB signaling lies one of the most crucial pathway. NR4a1 also manipulates the metabolism of inflammatory response of immune cells. In our study, we found that NR4a1 can promotes the cAMP signaling pathway and inhibits the LPS induced the activation of NFκB signaling and the mRNA level of IL-6 and IL-1β by down-regulating the PDE4B expression. Our study implied that NR4a1 plays a protective role with the potential to serve as an excellent therapy for inflammatory diseases.