Contribution to the field statement
Presence of hyperglycemia related to diabetes mellitus can negatively impact immune inflammatory responses in chronic periodontitis by influencing the antigen presenting dendritic cells. This study highlighted that hyperglycemia impacted immunometabolism of dendritic cells towards glycolysis and subsequent pro-inflammatory phenotypes. Understanding dendritic cells’ dysregulation may explain the conflicting adaptive immune cell profiles observed in diabetes mellitus and chronic periodontitis.
Figure 1.
A B