Contribution to the field statement
Presence of hyperglycemia related to diabetes mellitus can negatively
impact immune inflammatory responses in chronic periodontitis by
influencing the antigen presenting dendritic cells. This study
highlighted that hyperglycemia impacted immunometabolism of dendritic
cells towards glycolysis and subsequent pro-inflammatory phenotypes.
Understanding dendritic cells’ dysregulation may explain the conflicting
adaptive immune cell profiles observed in diabetes mellitus and chronic
periodontitis.
Figure 1.
A B