The aim of this article was to investigate the effect of structured handouts lectures and oral discussions on the academic performance of biochemistry students. The biochemistry course of science Bachelor students was implemented through structured handouts lectures using the lecturer and the mobile as information sources , oral discussions and practical sessions. The opinion of the students about the instruction methods was investigated through a questionnaire. The academic performance of the students was compared to the performance of a previous student batch who studied the course through traditional lectures and practical sessions only. The obtained results were analyzed using the SPSS program and the t-test percent. According to the university regulations the pass mark was set as 60. 85.9% was the percentage of pass students who studied the course through the structured handouts , oral discussion and practical session while the percentage of the pass students who studied the course through traditional lectures and practical sessions was 78.8%. However, the difference between the two percentages was insignificant (p- value= 0.25). The questionnaire analysis showed that 63.2% of the students believed that the structured handouts lectures and the oral discussions were excellent and 79.4% of the students advised the course coordinator to adopt this teaching method for the future batches. structured handouts lectures and oral discussions improved the performance of biochemistry students and they advised to adopt the method for future batches of biochemistry.