3.6 Neuroprotective activity
The neuroprotection activity is related to prevent the disease progression and other injuries due to the loss of neurons and halting. The cognitive disorders and many other neuronal dysfunctions are treated with the use of medicinal plants and mulberry is most prominent among all. Recent studies reports that the phenolic compounds, anthocyanins and flavonoids possess neuroprotective effects [63,64]. The polyphenols and alkaloids present in mulberry leaves can improve the cognitive function and also suspend the neural-degeneration [65].The isolated compounds from mulberry leaves can be used as neuroprotective agents for neurodegenerative diseases treatment [66]. One of the most common diseases with neurodegenerative disorder is Alzheimer’s diseases. The extract of mulberry leaves reduces the risk of Alzheimer’s disease. The leaf extract inhibit the amyloid β-peptide (1-42) fibril formation and attenuation of amyloid β-peptide (1-42) induced neurotoxicity [67]. The mechanism of neuroprotective activity is shown in figure 15.