3.6 Neuroprotective activity
The neuroprotection activity is related to prevent the disease
progression and other injuries due to the loss of neurons and halting.
The cognitive disorders and many other neuronal dysfunctions are treated
with the use of medicinal plants and mulberry is most prominent among
all. Recent studies reports that the phenolic compounds, anthocyanins
and flavonoids possess neuroprotective effects [63,64]. The
polyphenols and alkaloids present in mulberry leaves can improve the
cognitive function and also suspend the neural-degeneration [65].The
isolated compounds from mulberry leaves can be used as neuroprotective
agents for neurodegenerative diseases treatment [66]. One of the
most common diseases with neurodegenerative disorder is Alzheimer’s
diseases. The extract of mulberry leaves reduces the risk of Alzheimer’s
disease. The leaf extract inhibit the amyloid β-peptide (1-42) fibril
formation and attenuation of amyloid β-peptide (1-42) induced
neurotoxicity [67]. The mechanism of neuroprotective activity is
shown in figure 15.