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\begin{document}

\title{Infliximab-induced depression and Suicidal behaviour: a serious adverse
event to consider}



\author[1]{Maissa Thabet}%
\author[1]{Wissal Ben Yahia}%
\author[1]{Neila Fathallah}%
\author[1]{Ahmed Guiga}%
\author[1]{amira atig}%
\author[2]{bouraoui ouni}%
\author[1]{Neirouz Ghannouchi }%
\affil[1]{University of Sousse}%
\affil[2]{Medecine university}%


\vspace{-1em}



  
  \date{May 26, 2024}


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\selectlanguage{english}
\begin{abstract}
Infliximab (INF) is a biological widely used in the treatment of various
auto-immune diseases including Beh\selectlanguage{ngerman}çet's disease. INF and other
pro-inflammatory cytokines, has been retained in some cases as a factor
in the pathogenesis of various neuropsychiatric conditions. Herein we
present the case of an adult man with Behçet's disease (BD) who
developed acute depression leading to suicide after the fourth infusion
of infliximab. The patient did not experience disabling depressive
syndrome, or suicidal thoughts before. He has never made a prior suicide
attempt. He denied any previous episodes of mania or psychosis or a
history of trauma. Our patient received a serotonin reuptake inhibitor
with a good response which allowed us to maintain infliximab therapy.%
\end{abstract}\selectlanguage{ngerman}%



\sloppy


Maissa Thabet\textsuperscript{1}, Wissal Ben Yahia\textsuperscript{1},
Neila Fathallah\textsuperscript{2}, Ahmed Guiga\textsuperscript{1},
Amira Atig\textsuperscript{1}, Bouraoui Ouni\textsuperscript{2}, Neirouz
Ghannouchi\textsuperscript{1}

1. Internal Medicine Department, Farhat Hached University Hospital,
Faculty of Medicine of Sousse, Sousse, Tunisia.

2. Department of Pharmacology, Faculty of Medicine of Sousse, Sousse,
Tunisia.

\textbf{Maissa Thabet}

Internal Medicine Department, Farhat Hached University Hospital, Faculty
of Medicine of Sousse, Sousse, Tunisia.\emph{Maissa.thabet22@gmail.com}

\textbf{Wissal Ben Yahia}

Internal Medicine Department, Farhat Hached University Hospital, Faculty
of Medicine of Sousse, Sousse, Tunisia.

\emph{wissalbenyahia@gmail.com}

\textbf{Neila Fathallah}

Department of Pharmacology, Faculty of Medicine of Sousse, Sousse,
Tunisia.

\emph{neilafathallah@gmail.com}

Internal Medicine Department, Farhat Hached University Hospital, Faculty
of Medicine of Sousse, Sousse, Tunisia.

\textbf{Ahmed Guiga}

Internal Medicine Department, Farhat Hached University Hospital, Faculty
of Medicine of Sousse, Sousse, Tunisia.

\emph{guigaahmad@gmail.com}\textbf{}

\textbf{Amira Atig}

Internal Medicine Department, Farhat Hached University Hospital, Faculty
of Medicine of Sousse, Sousse, Tunisia.\emph{docamiraatig@gmail.com}

\textbf{Bouraoui Ouni}

Department of Pharmacology, Faculty of Medicine of Sousse, Sousse,
Tunisia.

\emph{elounibouraoui@yahoo.fr}

\textbf{Neirouz Ghannouchi}

Internal Medicine Department, Farhat Hached University Hospital, Faculty
of Medicine of Sousse, Sousse,
Tunisia.\emph{neirouz.ghannouchi@gmail.com}

Acknowledgments: No Grant support was taken

Funding statement: no funding to declare

Patient consent was taken

\textbf{Hosted file}

\verb`article Infliximab nov.doc`  available at \url{https://authorea.com/users/697967/articles/685876-infliximab-induced-depression-and-suicidal-behaviour-a-serious-adverse-event-to-consider}

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