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\begin{document}

\title{A nomogram with Ki-67 in the prediction of postoperative recurrence and
death for glioma}



\author[1]{Fengfeng Li}%
\author[2]{Dongyuan  Wang}%
\author[2]{Nana  Wang}%
\author[2]{Linlin  Wu}%
\author[2]{Bo  Yu}%
\affil[1]{Tengzhou Central People's Hospital}%
\affil[2]{The Affiliated Tengzhou Central People's Hospital of Xuzhou Medical University}%


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  \date{June 09, 2024}


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\begin{abstract}
Background: To evaluate the predictive value of a nomogram with Ki-67 in
overall and disease-free survival in glioma patients. Methods: A total
of 76 patients diagnosed with glioma were enrolled. The baseline data
and followups were retrospectively collected from medical records. The
associations between Ki-67 and survival status were examined using
log-rank test, univariate and multivariate Cox proportional hazard
regression models. Calibrations were performed to validate the
established nomograms. Results: Ki-67 negative group showed a longer OS
survival time and a longer PFS survival time with log-rank test
(x2=16.101, P\textless{}0.001 and x2=16.961, P\textless{}0.001). Age
older than 50 years (HR=2.074, 95\% CI: 1.097-3.923), abnormal treatment
(HR=2.932, 95\% CI: 1.343-6.403) and Ki-67 positive (HR=2.722, 95\% CI:
1.097-6.755) were the independent predictive factors of death. High
grade pathology (HR=2.453, 95\% CI: 1.010-5.956) and Ki-67 positive
(HR=2.200, 95\% CI: 1.043-4.639) were the independent predictive factors
of recurrence. The C-index for the nomogram of OS and PFS were 0.745 and
0.723, respectively. The calibration results showed that the nomogram
could predict the overall and disease-free 1-year survival of glioma
patients. Conclusion: The nomograms with Ki-67 as independent risk
factor for OS and PFS could provide clinical consultation in the
treatment and follow-up of malignant glioma.%
\end{abstract}%



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\textbf{Hosted file}

\verb`Manuscript-cancer reports.doc`  available at \url{https://authorea.com/users/697762/articles/685814-a-nomogram-with-ki-67-in-the-prediction-of-postoperative-recurrence-and-death-for-glioma}

\textbf{Hosted file}

\verb`Fig.docx`  available at \url{https://authorea.com/users/697762/articles/685814-a-nomogram-with-ki-67-in-the-prediction-of-postoperative-recurrence-and-death-for-glioma}

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