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Potential impact of climate change-induced alterations on pyroptotic cell death in animal cells
  • Caglar BERKEL
Tokat Gaziosmanpasa Universitesi Fen Edebiyat Fakultesi

Corresponding Author:[email protected]

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Climate change-induced alterations in temperature variation, ozone exposure, water salinity and acidification, and hypoxia might influence immunity in diverse animal groups from fish to mammals. Pyroptosis is a type of lytic pro-inflammatory programmed cell death, which participates in the innate immune response, and is involved in multiple diseases characterized by inflammation and cell death, mostly studied in human cells. Here, I review previous research pointing to the potential impact of climate change on pyroptotic cell death in different animal cells. I propose that temperature-, ozone exposure-, salinity-, acidification- and hypoxia-induced pyroptotic cell death should be better understood to be able to mitigate the adverse effects of climate change on animal physiology. This is of high importance considering the increasing frequency of climate-based changes in these environmental parameters, and the critical function of pyroptosis in immune responses of animals.