Association results from the eight selected association methods in the 50 cases and 50 controls : Fisher's exact test , VT, C-alpha, CAVIARBF, Elastic net, Blossoc, Naive Mantel test and Informed Mantel test. The horizontal dashed line represents the
5% significant threshold based on permutation and adjusted for multiple testing across the entire genomic
region. The red vertical dashed lines represent the disease risk region. (a) Manhattan plot for Fisher's exact test. The base-10 logarithm of the
association p-values is plotted against physical positions of SNVs. (b) Manhattan plot for VT test. (c) Manhattan plot for C-alpha test. P-values of both VT test and C-alpha test obtained from applying the VT test and C-alpha test across the simulated region using sliding windows of 20 SNVs overlapping by 5 SNVs. (d) Variable-inclusion probabilities (VIPs) for SNVs computed from elastic-net. (e) Posterior inclusion
probabilities (PIPs) computed from CAVIARBF. (f) Clustering scores for each SNV across the region, using the probability scores criterion in Blossoc. (g) Naive Mantel statistics for each tree position (SNV) across the simulated region. (h) Informed Mantel statistics for each tree position (SNV) in the genomic region.