What this study adds:
Attention should be paid to patients with age, male sex, obesity,
hypertension, hepatic and renal insufficiency, anemia, and other
underlying diseases.
Monitor creatine kinase and related indexes when using myotoxic drugs,
to avoid the occurrence of serious adverse reactions.
Automatic monitoring of drug adverse reactions makes pharmacovigilance
more efficient, large sample study more feasibility.
ABSTRACT OBJECTIVE : To analyze clinical characteristics,
incidence, and distribution of drug associated muscle adverse reaction
(DAMAR) in real world inpatients, to provide references for clinical
medication use. METHODS : Automated retrospective monitored
inpatients from 2022-5-1 to 2023-4-30 to obtain information about
patients’ adverse reactions and analyze. RESULTS : There were
1106 DAMARs among 102430 hospitalizations, with an incidence of 1.08%,
in which 125 cases of rhabdomyolysis with an incidence of 0.12%. 75%
of the patients experienced muscle adverse reactions within 5 days after
medication, and the median value of elevated CK was 420.4 IU/L. There
was no significant correlation between duration of surgery and the
elevation of CK, while the surgical procedure had an effect. Age, male
sex, obesity, hypertension, hepatic and renal insufficiency, anemia, and
other underlying diseases were risk factors. The 114 drugs involved were
mainly nervous system drugs, antiinfectives for systemic use and
cardiovascular system drugs, with levofloxacin, pregabalin and parecoxib
being the drugs with the highest number of cases. CONCLUSION :
Attention should be paid to patients with the above risk factors.
Monitor creatine kinase and related indexes when using myotoxic drugs,
to avoid the occurrence of serious adverse reactions, which may affect
the patients’ quality of life.