Clinical characteristics
The median hospitalization duration was 18 days, the occurring time of DAMAR was concentrated in 5 days after administration, which need us focus more on patients with relevant risk factors in the preceding days after using muscle-toxic drugs. Increased CK value of patients followed a skewed distribution, which might associate with some patients’ severe damage result in rapid growth [18]. Surgery also influences on muscle, resulting in CK increasing[19], surgery duration was considered as an important factor of CK increasing. Our study found weak correlation between surgery duration and CK values. Some literature[20] reported that CK significantly increased patients generally accompanied with surgery duration over 7 hours or most severely obese. Few patients in our study conformed to the situation, which might be the reason of weak correlation.