Comparison of the pathogen distribution and mortality among AYAs, Children and Adult
Among the 363 positive samples, the proportion of gram-negative bacteria (GNB) was 66.8%. According to our data, the main pathogenic bacteria in the BSIs at our center were GNB. We compared the pathogen distribution (Fig.2A) and summarized several common bacteria among the three groups (Table 2). AYAs patients were similar to adults in the etiology of BSIs and had a significant difference from children. Specifically, GNB occurred more frequently in AYAs and adults (78.3% vs. 72.7%), with Escherichia coli being the single most common organism responsible for BSIs in AYAs and adult cases (33.9% vs. 38.2%), whereas other isolated GNB organisms in AYAs included K. pneumoniae (22.8%) and P. aeruginosa (6.8%). In the pediatric population, gram-positive coagulase-negative Staphylococcus (CoNS) was the leading organism associated with BSIs (27.4%), whereas K. pseudomonas was the most common GNB organism isolated from children (16.4%). Meanwhile, 26 patients experienced IFI, giving an incidence of 10 (5.6%), 5 (6.8%), and 11 (10%) in the children, AYAS, and adult groups, respectively. We further compared the mortality rates among the groups (Fig. 2B). There was no significant difference between AYAs and adults (GNB:14.2% vs. 21.3%, P=0.176; GPB:20.7% vs. 21.1%, P=0.976; IFI:30% vs. 36.4%, P=0.757).