CONCLUSION:
Not only is our patient’s case of asynchronous primary breast lymphoma
rare but having a 27-year gap between diagnoses has never previously
been documented in the literature to our knowledge. There was no
evidence for currently known inheritable genes for lymphoma found in
this patient. Despite NCCN guidelines, mutual decision between patient
and provider was made to not utilize CNS prophylaxis.
Figure 1. Genes analyzed within INVITAE multi-Cancer Panel, Hereditary
Lymphoma Panel, and Preliminary Evidence Genes for Lymphoma Panel.