CONCLUSION:
Not only is our patient’s case of asynchronous primary breast lymphoma rare but having a 27-year gap between diagnoses has never previously been documented in the literature to our knowledge. There was no evidence for currently known inheritable genes for lymphoma found in this patient. Despite NCCN guidelines, mutual decision between patient and provider was made to not utilize CNS prophylaxis.
Figure 1. Genes analyzed within INVITAE multi-Cancer Panel, Hereditary Lymphoma Panel, and Preliminary Evidence Genes for Lymphoma Panel.