History of past illness
In 2015, the patient was diagnosed with uterine myoma at the age of 19.
In 2016, laparoscopic myomectomy was performed in a local hospital due
to the rapid growth of uterine myoma. The postoperative pathology was
uterine leiomyoma, and treatment with gonadotropin-releasing hormone
analog (GnRH-a) agonist for half a year. In 2019, the patient underwent
laparotomic myomectomy in Japan due to abnormal uterine bleeding and
recurrence of uterine myoma. The postoperative pathology was still
uterine leiomyoma. In 2020, the patient was in Japan, uterine myoma were
found to recur again in the follow-up ultrasound examination, and
received GnRH-a treatment again for half a year.
In July 2021, the patient was followed up in a hospital in Zhengzhou
after returning to China. Ultrasound showed multiple uterine myomas, the
largest size was 4.8×3.9cm, HPV16(+), TCT was LSIL, and HSIL could not
be excluded. A cervical biopsy was performed and the pathology report
was high-grade squamous intraepithelial lesion (HSIL/CIN III) with gland
involvement. In September 2021, the patient underwent cold-knife
conization in a hospital in Beijing. Postoperative pathology was
cervical tissue with chronic inflammation, HSIL at 4 and 5 o’clock,
glandular accumulation at 4 o’clock, small foci of HSIL at 8 o’clock,
HSIL at 6 and 5 o’clock, LSIL at 7 o’clock, and the incision is clean.