History of past illness
In 2015, the patient was diagnosed with uterine myoma at the age of 19. In 2016, laparoscopic myomectomy was performed in a local hospital due to the rapid growth of uterine myoma. The postoperative pathology was uterine leiomyoma, and treatment with gonadotropin-releasing hormone analog (GnRH-a) agonist for half a year. In 2019, the patient underwent laparotomic myomectomy in Japan due to abnormal uterine bleeding and recurrence of uterine myoma. The postoperative pathology was still uterine leiomyoma. In 2020, the patient was in Japan, uterine myoma were found to recur again in the follow-up ultrasound examination, and received GnRH-a treatment again for half a year.
In July 2021, the patient was followed up in a hospital in Zhengzhou after returning to China. Ultrasound showed multiple uterine myomas, the largest size was 4.8×3.9cm, HPV16(+), TCT was LSIL, and HSIL could not be excluded. A cervical biopsy was performed and the pathology report was high-grade squamous intraepithelial lesion (HSIL/CIN III) with gland involvement. In September 2021, the patient underwent cold-knife conization in a hospital in Beijing. Postoperative pathology was cervical tissue with chronic inflammation, HSIL at 4 and 5 o’clock, glandular accumulation at 4 o’clock, small foci of HSIL at 8 o’clock, HSIL at 6 and 5 o’clock, LSIL at 7 o’clock, and the incision is clean.