Conclusions
Whether HLRCC syndrome associated ULMs or sporadic ULMs, FH gene
deficiency may play an important role in its pathogenesis. FH mutation
screening is important when gynecologists encounter patients with early
onset and multiple ULMs, it can give early diagnosis and fertility
guidance. It is also helpful for early diagnosis of RCC. It is believed
that with the continuous progress of basic and clinical research on FH
gene, it can provide guidance for the clinical diagnosis of patients
with ULMs in the near future, and providing a new direction for the
treatment of ULMs.
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