Statistical analysis
Data were presented as means ± SEM. Statistical differences were
determined using unpaired Mann-Whitney test when comparing between two
independent groups, and Kruskall-Wallis test followed by a Dunn’s
post-hoc test when comparing across three or more independent groups. p
value < 0.05 was considered significant. The tumoral growth
analysis was performed thanks to a linear mixt model (longitudinal
data), including the time influence (intra and inter day variability)
and random intercept (intra and inter individual variability). In order
to obtain a reliable statistical model, the tumoral volume was converted
into a decimal logarithmic scale. Survival analysis was done using a log
rang model to compare survival curves and to calculate survival medians.