Results
Data of 15 patients in combination group and 43 patients in control
group were evaluated and included into the study. Of these patients
73.3% was male in combination arm and 72.1% in control group (p=0.9).
Demographic findings and frequency of comorbidities were similar between
two groups (table 1). Overall mortality was 46.7% (n=7) in combination
arm and 69.8% (n=30) in control group although it was not statistically
significant (p=0.1). Similarly, need of intubation was also lower in
combination arm (46.7%) compared to control group (69.8%), it was not
significantly different (p=0.1). ICU admission was significantly lower
in combination (46.7%, n=7) arm than control group (76.7%, n=33)
(p=0.03, Odds ratio [OR]:4.7). Development of severe infection
(20%, n=3 vs 25%, n=9/36), pulmonary embolism (6.7%, n=1 vs 0),
myocardial infarction (6.7%, n=1 vs 2.6%, n=1/38) and pneumothorax
(13.3%, n=2 vs 2.6%, n=1/38) were not different between two groups
(p=0.7, p=0.3, p=0.5 and p=0.2). In multivariable analysis only cHIS
score was associated with high mortality (p=0.018, OR:2.8, [95%
confidence interval: 1.2-6.6]). In survival analysis, mortality rate
was significantly lower in combination arm than control group
(Log-Rank:p=0.04;figure 1).