Abstract
Introduction: Coexistence of scleroderma with multiple myeloma is an unusual finding with unclear significance. Only 15 cases of MM with scleroderma have been reported until now.
Case presentation : We report a case of a 58-year-old female with 10-year history sceroderma, complaining from pallor and fatigue. The initial workup showed a normocytic anemia with elevated ESR and total proteins. On fruther investigation the gamma globulines were also high and the bone marrow biopsy showed interstitial and focal increase in plasma cells without bone marrow fibrosis. Skeletal survey showed osteopenia, but no osteolytic lesion or fracture. The patient was diagnosed as scleroderma with coexistence of immunoglobulin G (IgG) , kappa (κ) MM.
Conclusion: In view of the possible coexistence of scleroderma with MM, it is suggested that all patients with scleroderma should be screened for monoclonal gammopathy and MM regarding their age. future studies should be directed to determine the exact mechanism of these two conditions association and the effect of MM treatment on SSc improvement.
Keywords : Systemic Sclerosis (SSc),Multiple Myeloma ( MM), Osteolytic lesion, Immunoglobulin G, κ MM