Enrichment Analysis
GO analysis was performed on the differential genes. The number of
differential genes included in each GO entry was count. Hypergeometric
distribution algorithm was used to calculate the significance of the
enrichment of differential genes in each GO entry. The result of
calculation will return a p-value with rich significance. The lower the
value is, the more significant it is statistically. The enrichment
significance of each term in BP, CC and MF was calculated by Fisher’s
exact test. The KEGG data is used to carry out the pathway analysis of
differential genes, and the hypergeometric distribution algorithm is
used to calculate the significance of the enrichment of differential
genes in each pathway. The smaller the p-value, the higher the
correlation between the corresponding pathway and this differential
gene.