Enrichment Analysis
GO analysis was performed on the differential genes. The number of differential genes included in each GO entry was count. Hypergeometric distribution algorithm was used to calculate the significance of the enrichment of differential genes in each GO entry. The result of calculation will return a p-value with rich significance. The lower the value is, the more significant it is statistically. The enrichment significance of each term in BP, CC and MF was calculated by Fisher’s exact test. The KEGG data is used to carry out the pathway analysis of differential genes, and the hypergeometric distribution algorithm is used to calculate the significance of the enrichment of differential genes in each pathway. The smaller the p-value, the higher the correlation between the corresponding pathway and this differential gene.