Results of gene enrichment analysis
The GO analysis results of deleted OMIM gene showed that the first three terms of smallest p-value were serine-type endopeptidase inhibitor activity (Term ID: GO: 0004867), carboxypeptidase activity (Term ID: GO: 0004180) and translation from RNA polymerase II promoter (Term ID: GO: 0006366) [Figure 4 (A)]. Results of KEGG analysis showed that the first three paths with the smallest p-value were histidine metabolism (Term ID: path: hsa00340), beta-Alanine metabolism (Term ID: path: hsa00410) and arginine and line metabolism (Term ID: path: hsa00330) [Figure 4 (B)]. GO analysis results of duplicated OMIM genes showed that the first three terms with the smallest p-value were anchored component of membrane (Term ID:GO:0031225), C-terminal protein lipidation (Term ID:GO:0006501) and cell response to potassium ion (Term ID: GO: 0035865) [Figure 4 (C)]. The entry with statistical significance in the KEGG analysis results was aldosterone synthesis and secretione (Term ID:path:hsa04925) [Figure 4 (D)].