NCT Number Compund GPCR action GPCR Class  Receptor class Study Title
NCT03764098 Guanfacine Yes Class A Adrenoceptors Mechanistic Evaluation of Guanfacine on Drinking Behavior in Women and Men With Alcohol Use Disorders
NCT04827056 Dexmedetomidine Yes Class A Adrenoceptors Effect of Sublingual Formulation of Dexmedetomidine HCl (BXCL501) - Alcohol Interaction Study
NCT04135846 Doxazosin Yes Class A Adrenoceptors Alpha-1 Blockade for Alcohol Use Disorder (AUD)
NCT03137082 Guanfacine Yes Class A Adrenoceptors Guanfacine to Reduce Relapse Risk in Women With Alcohol Use Disorder (AUD)
NCT04793685 Prazosin Yes Class A Adrenoceptors Prazosin for Alcohol Use Disorder With Withdrawal Symptoms
NCT05317546 Cannabidiol Yes Class A Canabiniod Cannabidiol in Youth Alcohol Use Disorder
NCT04873453 Cannabidiol Yes Class A Canabiniod CBD for the Treatment of Alcohol Use Disorder
NCT05613608 Cannabidiol Yes Class A Canabiniod Alcohol Use Disorder and Cannabidiol
NCT05159830 Cannabidiol Yes Class A Canabiniod Cannabidiol for Reducing Drinking in Alcohol Use Disorder
NCT05387148 Cannabidiol Yes Class A Canabiniod The Efficacy and Neurobehavioural Mechanism of Cannabidiol (CBD) for Alcohol Dependence
NCT05860699 Cannabidiol Yes Class A Canabiniod Cannabidiol as an add-on Treatment During Inpatient Alcohol Cessation in Patients With Severe Alcohol Use Disorder: a Phase ii Trial
NCT04603781 Cannabidiol Yes Class A Canabiniod CBD Oil for Reducing Emotional Impact of COVID-19
NCT05781009 Pregnenolone Yes Class A Canabiniod Pregnenolone for the Treatment of Alcohol Use Disorder
NCT02461927 Naltrexone (+ Ketamine) Yes Class A Opioid Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder
NCT05919017 Naltrexone Yes Class A Opioid Exploring the PK of Different Doses of Naltrexone in Patients With AUD
NCT05028062 Naltrexone Yes Class A Opioid Naltrexone in AUD Reward Drinkers
NCT05656534 Suvorexant Yes Class A Orexin Orexin Receptor Antagonists as Modulators of Threat Sensitivity in Individuals With Alcohol Use Disorder
NCT05312008 Oxytocin Yes Class A Oxytocin Does Oxytocin Alter Tolerance to or Motivation for Alcohol
NCT03878316 Oxytocin Yes Class A Oxytocin Intranasal Oxytocin for the Treatment of Alcohol Use Disorder
NCT04071119 Oxytocin Yes Class A Oxytocin Alcohol and Cigarette Craving During Oxytocin Treatment
NCT04523922 Oxytocin Yes Class A Oxytocin Oxytocin to Enhance Integrated Treatment for AUD and PTSD
NCT03846505 Oxytocin Yes Class A Oxytocin Oxytocin to Enhance Alcohol Behavioral Couple Therapy (ABCT)
NCT05093296 Oxytocin Yes Class A Oxytocin Oxytocin and Naltrexone: Investigation of Combined Effects on Stress- and Alcohol Cue-induced Craving in Alcohol Use Disorder
NCT05674929 BPL-003 Yes Class A Serotonin An Open-Label, Single Dose Study in Patients With Alcohol Use Disorder
NCT05913752 CMND-100 Yes Class A Serotonin A First in Human Study of CMND-100 in Healthy and Alcohol Use Disorder (AUD) Subjects
NCT05474989 LSD Yes Class A Serotonin LSD Treatment for Persons With Alcohol Use Disorder
NCT05943665 MDMA Yes Class A Serotonin MDMA for AUD/PTSD Comorbidity
NCT05709353 MDMA Yes Class A Serotonin MDMA-assisted Prolonged Exposure Therapy for Comorbid Alcohol Use Disorder and Post-traumatic Stress Disorder
NCT05416229 Psilocybin Yes Class A Serotonin Psilocybin-assisted Therapy for Treatment of Alcohol Use Disorder
NCT04410913 Psilocybin Yes Class A Serotonin Pilot Trial of Visual Healing® in Psilocybin-assisted Therapy for Alcohol Use Disorder
NCT05646303 Psilocybin Yes Class A Serotonin Psilocybin-Assisted Psychotherapy in Adults With Alcohol Use Disorder (AUD)
NCT04141501 Psilocybin Yes Class A Serotonin Clinical and Mechanistic Effects of Psilocybin in Alcohol Addicted Patients
NCT04718792 Psilocybin Yes Class A Serotonin Psilocybin for Treatment of Alcohol Use Disorder: a Feasibility Study
NCT04620759 Psilocybin Yes Class A Serotonin Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use Disorder
NCT05421065 Psilocybin Yes Class A Serotonin Psilocybin-Assisted vs Ketamine-Assisted Psychotherapy for Alcohol Use Disorder
NCT04066192 Brexpiprazole Yes Class A Serotonin & Dopamine Brexpiprazole in Alcohol Use Disorder
NCT03526354 Brexpiprazole Yes Class A Serotonin & Dopamine Brexpiprazole Study
NCT05520775 Semaglutide Yes Class B1 Glucagon Semaglutide for Alcohol Use Disorder
NCT05892432 Semaglutide Yes Class B1 Glucagon Clinical Trial of Rybelsus (Semaglutide) Among Adults With Alcohol Use Disorder (AUD)
NCT05891587 Semaglutide Yes Class B1 Glucagon Semaglutide Therapy for Alcohol Reduction - Tulsa
NCT05895643 Semaglutide Yes Class B1 Glucagon Does Semaglutide Reduce Alcohol Intake in Patients With Alcohol Use Disorder and Comorbid Obesity?
NCT04679142 Baclofen Yes Class C GABA Baclocur Post-Authorisation Safety Study in Real-life Settings in France
NCT04831684 GET73 Yes Class C Glutamate Novel mGluR5 Modulator Effects on Alcohol Drinking and MRI Outcomes
NCT04218357 Probenecid Yes Class T Taste Probenecid as Medication for Alcohol Use Disorder
NCT05870111 Citicoline No Citicoline in Youth Alcohol Use Disorder
NCT03896516 GLWL-01 No Manipulating Ghrelin Signaling Via GOAT Inhibition in Alcohol Use Disorder
NCT05830708 Lactobacillus sp. Probiotic No The Efficacy of Probiotics for the Treatment of Alcohol Use Disorder Among Adult Males
NCT05178069 Lactobacillus Rhamnosus GG No LGG Supplementation in Patients With AUD and ALD
NCT05807139 Spironolactone No Spironolactone in Alcohol Use Disorder (SAUD)
NCT05134857 Zonisamide No The Zonisamide and Reinforcement for Reducing Alcohol Use (ZARRA) Study
NCT04015869 Allopregnanolone No Effect of Allopregnanolone on Stress-induced Craving
NCT05223829 Brexanolone No Utility of Brexanolone to Target Stress-induced Alcohol Use Among Men and Women With Posttraumatic Stress Disorder
NCT04084860 CI-581a No The Role of Brief Potent Glutamatergic Modulation in Addressing Problem Drinking
NCT05042102 Donepezil No Donepezil and Cognitive Training for Alcohol Use Disorder (AUD)
NCT04098302 Dutasteride No Dutasteride Treatment for Reducing Heavy Drinking in AUD: Predictors of Efficacy
NCT04527185 Endotoxin No Effect of Endotoxin on Alcohol Consumption
NCT05414240 Ibudilast No Ibudilast for Treating Alcohol Use Disorder
NCT05661669 Ketamine No Ketamine for the Treatment for Alcohol Use Disorder in the ED
NCT04616781 Ketone Ester No Ketone Ester Intervention in Alcohol Use Disorder
NCT02989662 Mifepristone No INIA Stress and Chronic Alcohol Interactions: Glucocorticoid Antagonists in Heavy Drinkers
NCT03707951 N-acetylcysteine No N-Acetylcysteine for Adolescent Alcohol Use Disorder
NCT05408247 N-acetylcysteine No A Randomised Controlled Trial of N-acetylcysteine for the Management of Alcohol Use Disorder
NCT05899660 Omega-3 No Impact of Omega 3 in Alcohol Use Disorder
NCT03864146 Pioglitazone No Pioglitazone for the Treatment of Alcohol Use Disorder
NCT05107765 Pioglitazone No Effects of Pioglitazone on Stress Reactivity and Alcohol Craving
NCT04322305 Pregabalin No Pregabalin Trial for the Treatment of Alcohol Use Disorder
NCT02884908 Pregabalin No Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD
NCT04331288 PT150 No Effects of Ethanol on the Pharmacokinetics of PT-150 (Formerly ORG34517) (PT150 PK Study)
NCT04232800 Riboflavin No Riboflavin for Glutamate Reduction in Alcohol Withdrawal
NCT05902754 Sulforaphane No Broccoli Extract Supplementation in Older Adults With Alcohol Use Disorder
NCT03904498 Tolcapone No COMT Inhibition Among Individuals With Comorbid AUD/ADHD
NCT03176953 Topiramate No Topiramate and Prolonged Exposure
NCT04770493 Lamotrigine No Enhancing the Effects of Alcohol Treatment With Lamotrigine