3.3 Sensitivity analysis and pleiotropy detection
We conducted a series of measures to
avoid bias effects, including the sensitivity of MR analysis and the
potential pleiotropy of IVs for each phenotype. The leave-one-out method
indicated no outliers in Figure 4 (G), however, abnormal values were
found in the remainder of Figure 4. However, these outliers affected the
results could be ignored considering the other statistical methods (both
the MR-Egger intercept test and MR-PRESSO global test suggested no
statistical difference). Cochrane’s Q
test indicated that no significant heterogeneity was observed among the
selected SNPs except Genus. Oscillibacter. Because the IVW method was
used as the main analysis method in this study, therefore, our results
remain plausible. The detailed results are summarized in Table 2.