Analysis of Chromatin Accessibility Around HBV Integration Sites in PLC/PRF/5 Cells and Prediction of Related Transcription Factors. (A) The ATAC-seq signal density plots within 100 kb upstream and downstream of transcriptional active (green) and transcriptional inactive (blue) integration sites. (B) Dot plot of the ATAC-seq accessibility and integrated HBV DNA transcription level. (C) The NFYC transcription factor aggregates on chromosome 1 of PLC/PRF/5 cells and can impede Tn5 enzyme cleavage when it binds to DNA sequences, reducing the likelihood of cutting in regions marked by NFYC. (D) Predicted transcription factors that bind to the genome at 100 kb upstream and downstream near the HBV integration site.