Determinants of Severity due to Covid-19 Among Young AdultsMairembam Stelin Singh1, Tanya
Singh2, Mairaj Ahmed Ansari3, Sailu
Yellaboina4*1 Department of Biochemistry, Jamia Hamdard, New Delhi
, India2 Department of Biomedical Engineering, University of
Houston, Texas3 Department of Biotechnology, Jamia Hamdard, New
Delhi, India4 All India Institute of Medical Sciences, Bibinagar,
Hyderabad, Telangana 508126, India* Lead contact* Corresponding author: Dr. Sailu Yellaboina:sailu.bio@aiimsbibinagar.edu.inAbstractBackgroundCoronavirus disease (COVID-19) is an emerging infectious disease
affecting people of all ages, races, and countries, caused by the severe
acute respiratory syndrome coronavirus (SARS-CoV-2). The disease has
been shown to be more lethal in select individuals with existing
comorbidities and inflammation. Although the disease occurs in people of
all ages, a milder course has been observed in pediatric patients.
Evidence suggests that the burden of COVID-19 infection is lower in
hospitalized children than in their adult counterparts. To date, there
are few reports describing the factors responsible for acute COVID-19
severity in young adults and their differences in the elderly. In this
work, we aimed to review the factors responsible for determining the
most severe cases with chronic clinical manifestations by evaluating
their clinical presentations to close the gap and provide a potential
basis to address this relationship between severity and age. The lower
severity in young adults could be due to a variety of reasons, ranging
from immunologic factors to genetic composition. Our work helps classify
some of these factors, which appear to play a role in a small number of
critical cases. The characteristic ability of the younger human body to
fight this deadly disease may be a striking feature when trying to
manage patients belonging to the older age group.SettingAll settings, including hospitalized and community settings.PatientsChildren and young people (CYP) under 20 years of age with PCR and other
laboratory tests COVID -19 affected patients. Main results: Prevalence
of symptoms and signs of COVID -19.PurposeThere are limited data on the demographics and clinical features of SAR
-CoV-2 infection in children. Therefore, with this literature review, we
aim to uncover various factors responsible for the different severities
in pediatric patients. This will help us to better understand COVID -19
in different age groups.Keywords: COVID-19, Coronavirus, SARS-CoV-2, young adults,
Pediatric, severity, age.MethodsReferences for this review article were obtained by searching PubMed,
NCBI, EClinicalMedicine from lancet using relevant terms related to
2019-nCoV, COVID -19, and SARS-CoV2 in neonates and children. Previous
articles were not considered, and only articles published in English
were considered. A range of datasets was considered to provide an
analysis of severity and different symptoms in different age groups.