2.2.2 HI, LNSP, ALB
The variable genetic information for HI, LNSP, ALB in this study was
extracted from the Integrative Epidemiology Unit (IEU) GWAS database
(https://gwas.mrcieu.ac.uk/), which is a publicly available GWAS summary
database[14]. HI status was represented by “average total household
income before tax” of the GWAS summary dataset with 397,751 samples
output from GWAS pipeline using Phesant derived variables from
UKBiobank. The HI was collected using a 5-point scale corresponding to
the average total household income before tax, 1 being less than 18,000
pounds, 2 being18,000–30,999 pounds, 3 being 31,000–51,999 pounds, 4
being 52,000–100,000 pounds, and 5 being greater than 100,000 pounds.
Genetic instruments for lifetime number of sexual partners and age at
last live birth were extracted from the GWAS summary datasets of 378,882
and 170,248 samples, respectively, which were output from GWAS pipeline
using Phesant derived variables from UKBiobank.