2.2.3 SB and AC
The GWAS summary dataset for SB and AC was extracted from GWAS and the Sequencing Consortium of Alcohol and Nicotine use (GSCAN) (https://genome.psych.umn.edu/index.php/GSCAN).SB represented by smoking initiation (n =1,232,091) is a binary phenotype, indicating whether an individual had ever smoked regularly; AC is a continuous phenotype measured with drinks per week (n=941,280)[15].