2.2.2 HI, LNSP, ALB
The variable genetic information for HI, LNSP, ALB in this study was extracted from the Integrative Epidemiology Unit (IEU) GWAS database (https://gwas.mrcieu.ac.uk/), which is a publicly available GWAS summary database[14]. HI status was represented by “average total household income before tax” of the GWAS summary dataset with 397,751 samples output from GWAS pipeline using Phesant derived variables from UKBiobank. The HI was collected using a 5-point scale corresponding to the average total household income before tax, 1 being less than 18,000 pounds, 2 being18,000–30,999 pounds, 3 being 31,000–51,999 pounds, 4 being 52,000–100,000 pounds, and 5 being greater than 100,000 pounds. Genetic instruments for lifetime number of sexual partners and age at last live birth were extracted from the GWAS summary datasets of 378,882 and 170,248 samples, respectively, which were output from GWAS pipeline using Phesant derived variables from UKBiobank.