2.2.1 EA and CP
The variable genetic information for EA represented by “years of education” were extracted from the BOLT-LMM (a mixed-model association method) summary association statistics released by Loh, P. R. et al.[12], which were available on the GWAS catalogue website (https://www.ebi.ac.uk/gwas/). The GWAS summary dataset for CP was extracted from Social Science Genetic Association Consortium (SSAGC) Data Portal (http://thessgac.com). We extracted single-nucleotide polymorphisms(SNPs) for CP from a meta-analysis combined a published study of general cognitive ability (n=35,298) conducted by the Cognitive Genomics Consortium with new GWAS of cognitive performance in the UKB (n =222,543)[13].