Combined interventions
Dissanayake et al explored the utility of a combined intervention
approach in a 2x2 factorial trial where one group received a combination
of synbiotics and a ceramide-based emollient from birth to 6 months, a
second group received synbiotics only, a third group emollient alone and
a last group with no intervention (Table 1).38However, they found no differences in food sensitization or FA
prevalence by age 1 year between any of the groups. PreventADALL also
had four study arms: skin intervention alone; early allergenic food
introduction alone; combined skin and food intervention; and no
intervention. FA prevalence was only reduced in the arm receiving early
allergenic food introduction as compared to no intervention, akin to the
LEAP study,3 but no difference compared to the skin
intervention group.