Lesion Set Parameters in Association with AEPVRs
Univariate analysis of the lesion set parameters showed the patients with AEPVR had a lower impedance drop (P =0.013) including the regional impedance drop on the posterior wall (P =0.009), lower AI in the whole left atrium (P =0.039) and the posterior wall AI(P =0.005) compared to the patients without AEPVR. Among patients with PVR, AEPVR group had a lower inter-lesion distance (P =0.003) and a slightly lower contact force (P =0.057) compared to Gap group (Supplementary Table 1).
Multivariable logistic regression models were then performed which were adjusted for all variables showing statistical difference in univariate analysis or of vital importance in clinical practice. As results, lower left atrium diameter (P <0.001), lower impedance drop (P =0.039) and AI (P =0.028) on the posterior wall were significantly associated with the presence of AEPVR. In patients with PVR, only a lower inter-lesion distance was independent predictor of AEPVR (P =0.045)(Table 3).
The ROC analysis was then performed to evaluate the performances between different prediction index, which demonstrated that the above-mentioned integrated prediction model for AEPVR containing multiple indicators had a larger area under curve (AUC=0.790) than single index including impedance drop, AI and contact force. So was the model established to predict AEPVR in patients with acute PVR, which also had the largest AUC of 0.786 (Figure 5).