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\begin{document}

\title{Global burden and cross-country inequalities in HCV-related liver
diseases from 1990 to 2019}



\author[1]{Junzhu Bai}%
\author[1]{Hengliang Lv}%
\author[2]{Leiliang Zhang}%
\author[3]{Longhao Wang}%
\author[1]{Shumeng You}%
\author[1]{Xin Zhang}%
\author[4]{Xuan Li}%
\author[5]{Yong Wang}%
\author[5]{Yuanyong Xu}%
\author[5]{Wenyi Zhang}%
\affil[1]{China Medical University Department of Epidemiology}%
\affil[2]{Shandong First Medical University}%
\affil[3]{Army Medical University}%
\affil[4]{Anhui Medical University Department of Epidemiology and Biostatistics}%
\affil[5]{Chinese PLA Center for Disease Control and Prevention}%


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  \date{June 15, 2024}


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\begin{abstract}
\textbf{Background \& Aims:} Acute hepatitis, cirrhosis and other
chronic liver diseases, and liver cancer caused by hepatitis C virus
(HCV) are have imposed a sever burden at the global. The study aims to
describe the burden and inequality analysis of HCV-related liver
diseases at the global. \textbf{Methods:} Our study utilized data from
the Global Burden of Diseases (GBD) 2019. Age-standardized rate of
incidence (ASIR), prevalence (ASPR), death (ASDR), and
disability-adjusted life years (DALYs) were employed to describe the
burden of HCV-related liver diseases across different populations and
regions worldwide. Additionally, we conducted an inequality analysis
using the slope index of inequality and concentration index to explore
the global disparities associated with HCV-related liver diseases
burden. \textbf{Results:} HCV-related diseases caused 542, 316 global
deaths in 2019. China (17\% of total infections) and India (10\% of
total infections) had the largest numbers of HCV-related disease, but
the ASPR was highest in Mongolia (9, 673.92 per 100, 000) and Cambodia
(5, 445.82 per 100, 000). The burden of Acute hepatitis C (AHC) was more
common in low socio-demographic index (SDI) regions, while HCV-related
liver cancer caused more large burden among the regions with higher SDI.
\textbf{Conclusions:} The burden of HCV-related liver diseases was still
at a relatively high level worldwide, and SDI was a significant factor
for differential distribution of the disease. Countries in the world
should take active parts in alleviating the burden of HCV-related liver
diseases, and take targeted measures according to their specific
circumstances.%
\end{abstract}%



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