Day -1 Day 7 Day 14 Day 28 Day 42
Midazolam (po) Cmax (ng mL-1) n 20 20 20 20 20
Mean ± SD 30.9 ± 9.8 50.5 ± 14.1 56.6 ± 14.4 33.7 ± 11.5 33.3 ± 9.5
Geometric mean 29.6 48.6 54.9 31.9 32.1
95% CI 25.8 – 33.9 42.6 – 55.6 48.7 – 61.8 27.1 – 37.5 28.2 – 36.5
AUC0-t (ng h mL-1) n 20 20 20 20 20
Mean ± SD 74.5 ± 21.9 198.7 ± 52.2 225.1 ± 50.0 83.9 ± 26.1 80.1 ± 23.8
Geometric mean 71.6 192.9 219.9 80.0 77.0
95% CI 62.5 – 82.0 171.9 – 216.4 198.3 – 243.9 68.8 – 93.1 67.2 – 88.1
Tmax (h) n 20 20 20 20 20
Median (min, max) 0.5 (0.5, 1.0) 0.5 (0.5, 2.0) 0.5 (0.5, 2.0) 0.5 (0.5, 1.0) 0.5 (0.5, 2.0)
t1/2 (h) n 20 20 20 20 20
Mean ± SD 4.4 ± 0.9 4.2 ± 0.8 4.3 ± 0.9 4.1 ± 0.9 4.3 ± 1.0
Geometric mean 4.2 4.1 4.2 4.1 4.2
95% CI 3.8 – 4.8 3.7 – 4.5 3.8 – 4.7 3.7 – 4.5 3.8 – 4.6
Prednisolone (po) Cmax (ng mL-1) n 20 20 20 20 19
Mean ± SD 156.1 ± 28.7 134.6 ± 21.3 138.0 ± 19.7 150.0 ± 28.6 134.4 ± 21.2
Geometric mean 153.6 133.1 136.8 147.6 132.8
95% CI 141.0 – 167.4 124.0 – 142.9 128.2 – 145.9 135.5 – 160.7 123.0 – 143.4
AUC0-t (ng h mL-1) n 20 20 20 20 19
Mean ± SD 571.6 ± 98.1 591.9 ± 76.4 631.0 ± 77.9 571.9 ± 96.5 553.2 ± 92.8
Geometric mean 562.7 586.7 625.9 563.8 545.6
95% CI 515.5 – 614.2 549.7 – 626.3 587.9- 666.4 519.2- 612.2 502.2- 592.8
Tmax (h) n 20 20 20 20 19
Median (min, max) 1.0 (0.5, 2.0) 1.5 (0.5, 3.0) 2.0 (0.5, 3.0) 1.0 (0.5, 3.0) 1.0 (0.5, 3.0)
t1/2 (h) n 20 20 20 20 19
Mean ± SD 2.2 ± 0.3 2.2 ± 0.2 2.3 ± 0.2 2.3 ± 0.2 2.1 ± 0.3
Geometric mean 2.2 2.2 2.3 2.2 2.1
95% CI 2.1 – 2.3 2.1 – 2.3 2.2 – 2.4 2.1 – 2.4 2.0 – 2.2
Atorvastatin (po) Cmax (ng mL-1) n 20 19 19 19 19
Mean ± SD 3.2 ± 1.5 3.1 ± 1.4 4.0 ± 2.4 3.3 ± 1.4 3.2 ± 1.5
Geometric mean 2.9 2.8 3.5 3.0 2.9
95% CI 2.3 – 3.7 2.3 – 3.5 2.8 – 4.5 2.5 – 3.8 2.3 – 3.6
AUC0-t (ng h mL-1) n 20 19 19 19 19
Mean ± SD 16.1 ± 6.2 28.2 ± 12.1 33.8 ± 13.8 17.9 ± 6.8 18.2 ± 6.2
Geometric mean 15.2 26.4 31.7 17.0 17.4
95% CI 13.1 – 17.7 22.3 – 31.3 26.8 – 37.6 14.5 – 19.9 15.0 – 20.0
Tmax (h) n 20 19 19 19 19
Median (min, max) 0.5 (0.5, 3.0) 3.0 (1.0, 10.0) 2.0 (1.0, 10.0) 0.5 (0.5, 6.0) 0.5 (0.5, 2.0)
t1/2 (h) n 20 19 19 19 19
Mean ± SD 9.2 ± 1.6 5.8 ± 1.3 4.5 ± 0.8 8.5 ± 2.2 8.5 ± 2.5
Geometric mean 9.1 5.7 4.4 8.3 8.2
95% CI 8.3 – 9.8 5.1 – 6.3 4.1 – 4.8 7.4 – 9.3 7.1 – 9.5
Midazolam (iv) AUC0-t (ng h mL-1) n 20 19 19 19 19
Mean ± SD 48.8 ± 12.1 67.4 ± 13.6 73.7 ± 14.5 56.0 ± 12.3 53.5 ± 11.6
Geometric Mean 47.5 66.0 72.4 54.7 52.2
95% CI 42.6 – 52.9 59.7 – 73.1 66.0 – 79.3 49.2 – 60.8 46.6 – 58.5
t1/2 (h) n 20 19 19 19 19
Mean ± SD 4.6 ± 1.5 4.5 ± 1.2 4.6 ± 1.0 4.0 ± 1.3 4.4 ± 1.5
Geometric Mean 4.3 4.3 4.5 3.8 4.1
95% CI 3.6 – 5.2 3.7 – 5.0 4.1 – 5.0 3.1 – 4.5 3.4 – 5.0