Graphene-Oxide Derived Magnetic Plasmonic Nanoplatforms |
Exploit the
high sensitivity of high plasmon-coupling nanoplatforms to develop a
more effective diagnostic that can distinguish between AD biomarkers
(i.e., tau fibrils and amyloid-β proteins) and whole blood serum |
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Specified |
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The graphene-oxide derived
magnetic plasmonic nanoplatforms are capable of identifying tau fibril
and amyloid-β concentrations, as low was 500 fg/mL. Additionally, the
synthesized nanoplatforms had significantly higher detection limits when
compared to conventional enzyme-linked immune sorbent assays (ELISA) |
122 |
Fe-MIL-88B-NH2 encapsulated with methylene blue
(inhibitor of tau aggregation) and functionalized with defluorinated
MK6240 and DMK6240 |
Formulate an advanced drug delivery system that
increases the bioavailability of methylene blue, improves
hyperphosphorylated tau targeting, enhances magnetic resonance imaging,
mitigates neuronal death, and ameliorates AD-related symptoms |
190-240
nm |
6.25, 12.5, 25, 50, 100 µg/mL |
SH-SY5Y cells |
Encapsulating
methylene blue within the magnetic-derived nanoparticle facilitated its
permeations across the BBB and enhanced its bioaccumulation in target
tissue. Furthermore, the synthesized NPs were able to effectively target
hyperphosphorylated tau, facilitate neuronal stability, decrease
inflammation and damage to hippocampal regions. In vivo studies
with AD rats that the conjugated NPs improved memory and cognition. |
123 |
Magnetic Iron-Oxide Nanoparticles coated with PEG-b-AGE and conjugated
with anti-amyloid-β and anti-tau antibodies |
Synthesize a
nanoparticulate system that offers more sensitive detection of tau and
amyloid-β proteins by limiting nonspecific interactions with increased
efficacy than conventional systems |
100-130 nm |
0.1, 0.5, 2.0, and 10
µg/mL |
CSF samples collected by lumbar punctures and whole blood serum
samples collected through veins |
The synthesized nanoparticles
exhibited a 90% improved specificity and a 95% improved sensitivity to
amyloid-β and tau biomarkers than conventional magnetic micron beads,
Dynabeads |
124 |