Nanoparticle Type Objective Size Dose Administered Experimental System Notable Results Reference
Methylene-Blue Loaded Mesoporous Silica Nanoparticles surface-conjugated with ultrasmall ceria nanocrystals and iron oxide nanocrystals
Develop an effective nanomaterial-based interventional system that can suppress tau hyperphosphorylation, limit mitochondrial oxidative stress, inhibit critical AD pathogenic pathways, and mitigate neuronal apoptosis
132 nm
0.0625, 0.125, 0.25, 0.5, 1.0 mM
In vitro: SH-SY5Y cells In vivo: Tauopathy AD rat models
The synthesized NPs were found to inhibit tau hyperphosphorylation & aggregation, prevent apoptosis of neurons, limit neuroinflammation, and function as a reactive oxygen species scavenger to decrease mitochondrial associated oxidative stress. Furthermore, in vivo studies indicated that the NPs alleviated memory and learning deficits caused by AD
126
Mesoporous silica nanoparticles functionalized with ceria-nanoparticles and anti-tau antibodies
Synthesize mesoporous silica nanoparticles to promote the clearance of tau aggregates, inhibit tau hyperphosphorylation, facilitate autophagy in neuronal cells, improve neuronal viability, and restore optimal cognitive function AD rat models
79 nm
2.5, 5, 10 µg/mL
In vitro: SH-SY5Y cells In vivo: AD rat model
The synthesized NPs were found to be successful in achieving biocompatibility, promoting autophagy, clearing tau aggregates, enhancing neuronal viability, and improving cognitive function in AD rats
127