Methylene-Blue Loaded Mesoporous Silica Nanoparticles surface-conjugated
with ultrasmall ceria nanocrystals and iron oxide nanocrystals
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Develop an effective nanomaterial-based interventional system that can
suppress tau hyperphosphorylation, limit mitochondrial oxidative stress,
inhibit critical AD pathogenic pathways, and mitigate neuronal
apoptosis
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132 nm
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0.0625, 0.125, 0.25, 0.5, 1.0 mM
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In vitro: SH-SY5Y cells
In vivo: Tauopathy AD rat models
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The synthesized NPs were found to inhibit tau hyperphosphorylation &
aggregation, prevent apoptosis of neurons, limit neuroinflammation, and
function as a reactive oxygen species scavenger to decrease
mitochondrial associated oxidative stress. Furthermore, in vivo
studies indicated that the NPs alleviated memory and learning deficits
caused by AD
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126
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Mesoporous silica nanoparticles functionalized with ceria-nanoparticles
and anti-tau antibodies
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Synthesize mesoporous silica nanoparticles to promote the clearance of
tau aggregates, inhibit tau hyperphosphorylation, facilitate autophagy
in neuronal cells, improve neuronal viability, and restore optimal
cognitive function AD rat models
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79 nm
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2.5, 5, 10 µg/mL
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In vitro: SH-SY5Y cells
In vivo: AD rat model
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The synthesized NPs were found to be successful in achieving
biocompatibility, promoting autophagy, clearing tau aggregates,
enhancing neuronal viability, and improving cognitive function in AD
rats
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127
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