Nanoparticle Type Objective Size Dose Administered Experimental System Notable Results References
Gold Nanoparticles conjugated with anti-tau antibodies Synthesize a highly sensitive AD diagnostic by monitoring tau protein concentrations Not Specified Not Specified Not Applicable The anti-tau antibody conjugated gold nanoparticles can detect significantly low tau protein concentrations of 1 pg/mL 105,112
Gold Nanoparticles surface-conjugated with polyA aptamer Synthesize a highly sensitive AD diagnostic by monitoring amyloid-β and tau protein concentrations Not Specified Not Specified Not Applicable The polyA aptamer conjugated gold nanoparticles show promising abilities to function as an AD diagnostic by monitoring amyloid-β and tau protein levels 113
Nanogold Polyethylene glycol (PEG) conjugate
Develop an interventional system that ameliorates AD symptoms by restoring normal tau protein mechanics and inhibiting amyloidoisis
180-260 nm
Not Specified
In vivo: transgenic tau P301L mice Ex vivo: Monkey and human serum samples
Nanogold PEG conjugates can diminish total tau and phosphorylated tau levels in in vivo mouse models. Additionally, ex vivo studies indicated the Gold-PEG nanoparticles repaired abnormal tau protein mechanics and contributed to the stabilization of proteotoxic tau
114
Folic-Acid functionalized gold nanoparticles Implement a nanoparticulate system that can treat AD by stabilizing microtubules and enhancing tau clearance Not Specified Not Specified Not Specified The folic-acid functionalized gold nanoparticles exhibited notable affinity for stabilizing tubulin proteins and clearing tau proteins 115
Gold Iron Oxide Core-Shell Nanoparticles Implement a nanoparticulate system that can treat AD by stabilizing microtubules and enhancing tau clearance Not Specified Not Specified Not Specified The folic-acid functionalized gold nanoparticles exhibited notable affinity for stabilizing tubulin proteins and clearing tau proteins 115