Figure 3: Post-translational modifications of tau protein, such as phosphorylation, ubiquitylation, and acetylation, can contribute to the toxic tau function in Alzheimer’s Disease. The accumulation of the toxic tau proteins can facilitate the following: changes in gene transcription, changes in autophagic clearance, mitochondrial dysfunction, disruption in microtubule transport, and synaptic interference. These changes contribute to neurodegeneration and neuronal death characterized in Alzheimer’s Disease.