Gold Nanoparticles conjugated with anti-tau antibodies |
Synthesize a
highly sensitive AD diagnostic by monitoring tau protein concentrations |
Not Specified |
Not Specified |
Not Applicable |
The anti-tau antibody
conjugated gold nanoparticles can detect significantly low tau protein
concentrations of 1 pg/mL |
105,112 |
Gold Nanoparticles surface-conjugated with polyA aptamer |
Synthesize a
highly sensitive AD diagnostic by monitoring amyloid-β and tau protein
concentrations |
Not Specified |
Not Specified |
Not Applicable |
The
polyA aptamer conjugated gold nanoparticles show promising abilities to
function as an AD diagnostic by monitoring amyloid-β and tau protein
levels |
113 |
Nanogold Polyethylene glycol (PEG) conjugate
|
Develop an interventional system that ameliorates AD symptoms by
restoring normal tau protein mechanics and inhibiting amyloidoisis
|
180-260 nm
|
Not Specified
|
In vivo: transgenic tau P301L mice
Ex vivo: Monkey and human serum samples
|
Nanogold PEG conjugates can diminish total tau and phosphorylated tau
levels in in vivo mouse models. Additionally, ex vivo
studies indicated the Gold-PEG nanoparticles repaired abnormal tau
protein mechanics and contributed to the stabilization of proteotoxic
tau
|
114
|
Folic-Acid functionalized gold nanoparticles |
Implement a
nanoparticulate system that can treat AD by stabilizing microtubules and
enhancing tau clearance |
Not Specified |
Not Specified |
Not Specified |
The folic-acid functionalized gold nanoparticles exhibited notable
affinity for stabilizing tubulin proteins and clearing tau proteins |
115 |
Gold Iron Oxide Core-Shell Nanoparticles |
Implement a nanoparticulate
system that can treat AD by stabilizing microtubules and enhancing tau
clearance |
Not Specified |
Not Specified |
Not Specified |
The
folic-acid functionalized gold nanoparticles exhibited notable affinity
for stabilizing tubulin proteins and clearing tau proteins |
115 |