Nanoparticle Type Objective Size Dose Administered Experimental System Notable Results Reference
Protein-capped iron oxide and cadmium sulfide nanoparticles
Synthesize a metallic-based nanoparticle that is effective in preventing tau aggregation and polymerization to function as a potential AD treatment
Protein-capped iron oxide nanoparticle: 40-50 nm Cadmium sulfide nanoparticle: 5-20 nm
5-100 µg/mL
Neuro2a neuroblastoma cell line
Both synthesized nanoparticles had optimal biocompatibility with the Neuro2a neuroblastoma cell line. Additionally, both nanoparticles served a synergistic effect to prevent tau accumulation and inhibit tau aggregation
116
Titanium Dioxide nanoparticles conjugated with porous nylon substrates Design a metallic-based nanoparticle that functions to provide more insight about the 7 in vivo phosphorylation sites that are often hyperphosphorylated in AD Not Specified Not Specified Not Specified The groundwork for the advancement of more targeted and efficient therapeutic interventions aimed at suppressing tau hyperphosphorylation is established 117