Figure 2¹⁹: Transcription, Post-Transcriptional Modifications, and Translation of tau protein from tau MAPT gene. Once the tau protein is transcribed, it undergoes alternative splicing and translation to form 6 different possible isoforms. 3 isoforms have 3 binding domains, while the other 3 isoforms have 4 binding domains. The regions (N-terminal, proline-rich, repeat domain, and C-terminal) are all shown on each tau protein isoform.