Curcumin-loaded liposomes functionalized with NGF, CL, and WGA
|
Synthesize a more effective curcumin-delivery system to decrease
phosphorylated tau levels and alleviate AD symptoms
|
130-145 nm
|
0.8-1.0 mg/mL
|
In vitro: SK-N-MC cells
In vivo: Wistar rats
|
The synthesized liposomes significantly downregulated the expression of
phosphorylated p38 proteins, phosphorylated tau protein levels, and
phosphorylated c-Jun N-terminal kinase. Furthermore, the liposomes
demonstrated excellent efficacy in improving BBB penetration, decreasing
amyloid-β accumulation, and preventing neurodegeneration.
|
107
|
Solid lipid nanoparticles (SLN) encapsulated with nicotinamide, a
histone deacetylase inhibitor
|
Design an interventional system to ameliorate AD symptoms by inhibiting
tau hyperphosphorylation and determine which functionalization
(polysorbate 80, phosphatidylserine, phosphatidic acid) was most
effective.
|
Polysorbate-80 functionalized nicotinamide-loaded SLNs: 112 nm
Phosphatidylserine-functionalized nicotinamide-loaded SLNs: 124 nm
Phosphatidic acid functionalized nicotinamide-loaded SLNs: 137 nm
|
15, 30, 60 mg/kg
|
In vitro: SH-SY5Y cells
|
In vitro studies confirmed the biocompatibility of the
phosphatidyl-serine and phosphatidic acid functionalized
nicotinamide-loaded SLNs. Biodistribution studies showed that the
synthesized SLNs improved brain delivery of nicotinamide. Furthermore,
Morris water maze tests and memory examinations supported that the
synthesized SLNs enhanced cognition, cultivated normal neuronal cell
functionalities, and inhibited tau hyperphosphorylation.
|
106
|
Apolipoprotein E3 (apoE3) and high density lipoprotein (HDL)
functionalized liposomes |
Create a nanostructure that is capable of
effectively permeating the BBB and enhancing amyloid-β and tau clearance |
Not Specified |
5 mg/kg |
In vivo: SAMP8 mice |
Detailed
studies indicated that the synthesized nanostructures could travel
across the BBB, stimulate amyloid-β and tau degradation, facilitate
microgliosis, reverse AD-induced neurologic changes, and restore memory
capabilities in AD mouse models. |
110 |
Liposomal nanoparticles encapsulated with tannic acid and coated with
Tween-80 |
Synthesize a liposomal nanoparticulate system focused on
inhibiting tau aggregation for applications in AD treatment |
Not
Specified |
Not Specified |
In vitro: SK-N-SH neuroblastoma cell
line and bEnd.3 mouse-derived microvascular brain endothelial cells |
Extensive in vitro studies indicated that the synthesized
nanoparticles could effectively traverse the BBB and decrease tau
aggregation induced tau peptide R3 fibrils |
111 |