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Author’ contributions: Fei Jiang had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Danni Wang. Acquisition, analysis, or interpretation of data: All authors. Drafting of the manuscript: Fei Jiang and Danni Wang. Critical revision of the manuscript for important intellectual content: All authors. Statistical analysis: Fei Jiang. Obtained funding: Danni Wang. Administrative, technical, or material support: Danni Wang. Study supervision: Danni Wang.
Acknowledgments: The authors would like to thank the Center for Reproductive Medicine, First Affiliated Hospital of Anhui Medical University for their technical support for data collection. The authors would also like to thank the study participants and staff.
Institutional Review Board Statement: The Ethics Committee of Anhui Medical University approved the study protocols (No. 20200961). And the study design was confirmed in accordance with the Helsinki Declaration.
Informed Consent Statement: All participants provided informed consent before enrollment.
Funding: This work was supported by the National Natural Science Foundation of China (72004001), and grants from Anhui Provincial Scientific Research and Humanities Project of Colleges and Universities (2022AH050627).
Disclosure statement: All authors have completed the ICMJE uniform disclosure form and have no conflicts of interest to declare.
Attestation statement: The subjects in this trial have not concomitantly been involved in other randomized trials. Data regarding any of the subjects in the study has not been previously published unless specified. Data will be made available to the editors of the journal for review or query upon request.
Data sharing statement: Data will be made available on request.
Word counting: 222 words for abstract and 3784 words for text.
Number of figures and tables : 3 tables, 2 figures, 2 supplemental tables, and 3 supplemental figures.