Neurodegenerative diseases impact the structure and operation of the
nervous system, causing progressive and irreparable harm. The absence of
distinguishable symptoms in the early stages of neurodegenerative
diseases makes diagnosis challenging. Additionally, it can be difficult
to pinpoint the precise neurodegenerative disorder affecting a patient
as the symptoms of these conditions frequently overlap. Numerous studies
have shown that pathological changes occur years before clinical signs
appear. Therefore, it is crucial to discover blood-based biomarkers for
neurodegenerative diseases for easier and faster diagnosis. Proximity
Extension Assay is a unique proteomics method that uses antibodies
linked to oligonucleotides for quantifying proteins with real-time PCR.
Proximity Extension Assay can identify even low-quantity proteins using
a small volume of specimens with increased sensitivity compared to
conventional methods. In this article, we reviewed the employment of
Proximity Extension Assay technology to detect biomarkers or protein
profiles for several neurodegenerative diseases.