Introduction
Left atrial appendage occlusion (LAAO) is an alternative to oral anticoagulants for prevention of stroke in patients with atrial fibrillation who are not optimal candidates for long-term anticoagulation. Acute thrombus formation on the delivery sheath during left atrial appendage occlusion is rare condition. Periprocedural stroke during LAAO is extremely unacceptable. We described the use of placement of cerebral embolic protection devices to prevent neurological events when acute thrombus formation during the implantation of LACbes (Shanghai PushMed, Shanghai, China).