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\begin{document}

\title{``SERUM PLACENTAL GROWTH FACTOR LEVELS AND UTERINE ARTERY DOPPLER
PULSATILITY INDEX AT 11-13 WEEKS 6 DAYS GESTATION AS EARLY PREDICTIVE
MARKERS OF PRE-ECLAMPSIA AT TERTIARY CARE HOSPITAL: A PROSPECTIVE
OBSERVATIONAL STUDY''}



\author[1]{deepika bohra}%
\author[1]{N. Sinchana}%
\author[1]{DR SUJATHA  M.S}%
\affil[1]{JSS Medical College}%


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  \date{May 21, 2024}


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\begin{abstract}
\textsuperscript{\textbf{ABSTRACT}} \textbf{OBJECTIVE}: To detect serum
placental growth factor levels and uterine artery doppler pulsatility
index for predicting pre-eclampsia and assess their association with the
severity of pre-eclampsia. \textbf{DESIGN}: Prospective observational
study \textbf{SETTING}: Tertiary care centre \textbf{POPULATION}: All
antenatal women from 11 to 13+6weeks gestation attending antenatal
clinic during study period. \textbf{METHODS}: This involved 160
antenatal women, from 11-13+6 weeks gestation. Serum PlGF levels and UA
doppler mean P.I measured and patients were followed up upto delivery
and observed for the development of pre-eclampsia and its severity.
\textbf{MAIN OUTCOME MEASURES}: PIGF Value cut-off was 40.33pg/ml with
the sensitivity of 97.5 \% and Specificity was 98.3\%. For the PI Value
of 1.85 the sensitivity was found to be 74.4\% and Specificity was found
to be 92.5\%. \textbf{RESULTS}: Mean serum PlGF levels for pre-eclampsia
patients was 25.09pg/ml and for normotensive patients mean PlGF level
was 65.05pg/ml. Mean UA doppler P.I for pre-eclampsia patients was 2.02
and for normotensive patients was 1.39. Mean PI value increased with
increasing severity of preeclampsia. \textbf{CONCLUSION}: Early
recognition of women will help initiation of prophylactic measures and
enhanced surveillance. First trimester UA Doppler with serum PlGF
together with maternal characteristics can be used as a reliable
screening test for preeclampsia prediction and to reduce feto-maternal
morbidity \textbf{KEYWORDS}: uterine artery (UA) doppler pulsality index
(P.I), placental growth factor levels(PlGF), pre-eclampsia, eclampsia%
\end{abstract}%



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