Characteristics of the model derivation cohort
In total, 819 patients with liver cirrhosis from Europe (Italy, Germany, Belgium, Denmark), the United States, China, Korea, and Australia who had undergone HVPG measurement were included in the derivation cohort. The main etiologies of chronic liver disease were viral (n=295), alcohol (n=214) and non-alcoholic fatty liver disease (n=150). The baseline characteristics of the derivation cohort were shown in sTable 1. The risk of bias and concerns regarding the applicability of the six included studies was low based on QUADAS-2 criteria, as presented in sFigure 2.