An international multicenter longitudinal follow-up cohort
The inclusion criteria: (1) adult age above or equal to 18 years old; (2) fulfilled liver cirrhosis diagnosis based on LSM, radiological, histological or clinical features. The exclusion criteria: (1) prior hepatic decompensation; (2) HCC; (3) prior liver transplantation; (4) portal vein thrombosis; (5) ongoing use of antiplatelet or anticoagulation; (6) incomplete follow-up data; (7) with NSBBs treatment.
A longitudinal carvedilol-treating cohort
The inclusion criteria: (1) adult age above or equal to 18 years old; (2) fulfilled liver cirrhosis diagnosis based on LSM, radiological, histological or clinical features; (3) high risk defined by CSPH risk model. The exclusion criteria: (1) prior hepatic decompensation; (2) HCC; (3) prior liver transplantation; (4) portal vein thrombosis; (5) ongoing use of antiplatelet or anticoagulation; (6) incomplete follow-up data.