References

Alexander, S. P., Christopoulos, A., Davenport, A. P., Kelly, E., Mathie, A., Peters, J. A., … Ye, R. D. (2021). THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. Br J Pharmacol, 178 Suppl 1 , S27-s156. doi:10.1111/bph.15538
Alexander, S. P. H., Christopoulos, A., Davenport, A. P., Kelly, E., Mathie, A., Peters, J. A., … Davies, J. A. (2019). THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors. Br J Pharmacol, 176 Suppl 1 (Suppl 1), S21-s141. doi:10.1111/bph.14748
Amiri Moghaddam, J., Dávila-Céspedes, A., Kehraus, S., Crüsemann, M., Köse, M., Müller, C. E., & König, G. M. (2018). Cyclopropane-Containing Fatty Acids from the Marine Bacterium Labrenzia sp. 011 with Antimicrobial and GPR84 Activity. Mar Drugs, 16 (10)doi:10.3390/md16100369
Audoy-Rémus, J., Bozoyan, L., Dumas, A., Filali, M., Lecours, C., Lacroix, S., … Vallières, L. (2015). GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer’s disease. Brain Behav Immun, 46 , 112-120. doi:10.1016/j.bbi.2015.01.010
Boyden, S. E., Desai, A., Cruse, G., Young, M. L., Bolan, H. C., Scott, L. M., … Komarow, H. D. (2016). Vibratory Urticaria Associated with a Missense Variant in ADGRE2. N Engl J Med, 374 (7), 656-663. doi:10.1056/NEJMoa1500611
Cawston, E. E., Redmond, W. J., Breen, C. M., Grimsey, N. L., Connor, M., & Glass, M. (2013). Real-time characterization of cannabinoid receptor 1 (CB1 ) allosteric modulators reveals novel mechanism of action. Br J Pharmacol, 170 (4), 893-907. doi:10.1111/bph.12329
Chen, L. H., Zhang, Q., Xiao, Y. F., Fang, Y. C., Xie, X., & Nan, F. J. (2022). Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis. J Med Chem, 65 (5), 3991-4006. doi:10.1021/acs.jmedchem.1c01813
Choi, M., Staus, D. P., Wingler, L. M., Ahn, S., Pani, B., Capel, W. D., & Lefkowitz, R. J. (2018). G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β(2)-adrenergic receptor. Sci Signal, 11 (544)doi:10.1126/scisignal.aar7084
Davenport, A. P., Alexander, S. P., Sharman, J. L., Pawson, A. J., Benson, H. E., Monaghan, A. E., … Harmar, A. J. (2013). International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev, 65 (3), 967-986. doi:10.1124/pr.112.007179
Dietrich, P. A., Yang, C., Leung, H. H., Lynch, J. R., Gonzales, E., Liu, B., … Wang, J. Y. (2014). GPR84 sustains aberrant β-catenin signaling in leukemic stem cells for maintenance of MLL leukemogenesis.Blood, 124 (22), 3284-3294. doi:10.1182/blood-2013-10-532523
Eiger, D. S., Boldizsar, N., Honeycutt, C. C., Gardner, J., & Rajagopal, S. (2021). Biased agonism at chemokine receptors.Cellular Signalling, 78 , 109862. doi:https://doi.org/10.1016/j.cellsig.2020.109862
Folts, C. J., Giera, S., Li, T., & Piao, X. (2019). Adhesion G Protein-Coupled Receptors as Drug Targets for Neurological Diseases.Trends Pharmacol Sci, 40 (4), 278-293. doi:10.1016/j.tips.2019.02.003
Foster, S. R., Hauser, A. S., Vedel, L., Strachan, R. T., Huang, X. P., Gavin, A. C., … Gloriam, D. E. (2019). Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors.Cell, 179 (4), 895-908.e821. doi:10.1016/j.cell.2019.10.010
Fredriksson, J., Holdfeldt, A., Mårtensson, J., Björkman, L., Møller, T. C., Müllers, E., … Forsman, H. (2022). GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting GPR84 agonists. Biochim Biophys Acta Mol Cell Res, 1869 (7), 119262. doi:10.1016/j.bbamcr.2022.119262
Gaidarov, I., Anthony, T., Gatlin, J., Chen, X., Mills, D., Solomon, M., … Unett, D. J. (2018). Embelin and its derivatives unravel the signaling, proinflammatory and antiatherogenic properties of GPR84 receptor. Pharmacol Res, 131 , 185-198. doi:10.1016/j.phrs.2018.02.021
Gao, W. S., Qu, Y. J., Huai, J., Wei, H., Zhang, Y., & Yue, S. W. (2020). DOK3 is involved in microglial cell activation in neuropathic pain by interacting with GPR84. Aging (Albany NY), 13 (1), 389-410. doi:10.18632/aging.202144
Grailhe, P., Boutarfa-Madec, A., Beauverger, P., Janiak, P., & Parkar, A. A. (2020). A label-free impedance assay in endothelial cells differentiates the activation and desensitization properties of clinical S1P(1) agonists. FEBS Open Bio, 10 (10), 2010-2020. doi:10.1002/2211-5463.12951
Hauser, A. S., Attwood, M. M., Rask-Andersen, M., Schiöth, H. B., & Gloriam, D. E. (2017). Trends in GPCR drug discovery: new agents, targets and indications. Nat Rev Drug Discov, 16 (12), 829-842. doi:10.1038/nrd.2017.178
Hauser, A. S., Gloriam, D. E., Bräuner-Osborne, H., & Foster, S. R. (2020). Novel approaches leading towards peptide GPCR de-orphanisation.Br J Pharmacol, 177 (5), 961-968. doi:10.1111/bph.14950
Huang, Q., Feng, D., Liu, K., Wang, P., Xiao, H., Wang, Y., … Liu, Z. (2014). A medium-chain fatty acid receptor Gpr84 in zebrafish: expression pattern and roles in immune regulation. Dev Comp Immunol, 45 (2), 252-258. doi:10.1016/j.dci.2014.03.017
I, K. Y., Tseng, W. Y., Wang, W. C., Gordon, S., Ng, K. F., & Lin, H. H. (2020). Stimulation of Vibratory Urticaria-Associated Adhesion-GPCR, EMR2/ADGRE2, Triggers the NLRP3 Inflammasome Activation Signal in Human Monocytes. Front Immunol, 11 , 602016. doi:10.3389/fimmu.2020.602016
Ichimura, A., Hirasawa, A., Hara, T., & Tsujimoto, G. (2009). Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis. Prostaglandins Other Lipid Mediat, 89 (3-4), 82-88. doi:10.1016/j.prostaglandins.2009.05.003
Insel, P. A., Sriram, K., Gorr, M. W., Wiley, S. Z., Michkov, A., Salmerón, C., & Chinn, A. M. (2019). GPCRomics: An Approach to Discover GPCR Drug Targets. Trends Pharmacol Sci, 40 (6), 378-387. doi:10.1016/j.tips.2019.04.001
Insel, P. A., Sriram, K., Wiley, S. Z., Wilderman, A., Katakia, T., McCann, T., … Murray, F. (2018). GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic Targets. Front Pharmacol, 9 , 431. doi:10.3389/fphar.2018.00431
Jayne, D. R. W., Merkel, P. A., Schall, T. J., & Bekker, P. (2021). Avacopan for the Treatment of ANCA-Associated Vasculitis. N Engl J Med, 384 (7), 599-609. doi:10.1056/NEJMoa2023386
Kamber, R. A., Nishiga, Y., Morton, B., Banuelos, A. M., Barkal, A. A., Vences-Catalán, F., … Bassik, M. C. (2021). Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis. Nature, 597 (7877), 549-554. doi:10.1038/s41586-021-03879-4
Kazmierski, W., Bifulco, N., Yang, H., Boone, L., DeAnda, F., Watson, C., & Kenakin, T. (2003). Recent progress in discovery of small-molecule CCR5 chemokine receptor ligands as HIV-1 inhibitors.Bioorg Med Chem, 11 (13), 2663-2676. doi:10.1016/s0968-0896(03)00161-5
Khalil, N., Manganas, H., Ryerson, C. J., Shapera, S., Cantin, A. M., Hernandez, P., … Kolb, M. (2019). Phase 2 clinical trial of PBI-4050 in patients with idiopathic pulmonary fibrosis. Eur Respir J, 53 (3)doi:10.1183/13993003.00663-2018
Kolakowski, L. F., Jr. (1994). GCRDb: a G-protein-coupled receptor database. Recept Channels, 2 (1), 1-7.
Köse, M., Pillaiyar, T., Namasivayam, V., De Filippo, E., Sylvester, K., Ulven, T., … Müller, C. E. (2020). An Agonist Radioligand for the Proinflammatory Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights. J Med Chem, 63 (5), 2391-2410. doi:10.1021/acs.jmedchem.9b01339
Laschet, C., Dupuis, N., & Hanson, J. (2018). The G protein-coupled receptors deorphanization landscape. Biochem Pharmacol, 153 , 62-74. doi:10.1016/j.bcp.2018.02.016
Li, S. X., Wang, S. W., Chen, L. H., Zhang, Q., Lu, D., Chen, J., … Nan, F. J. (2023). Unsymmetrical Phosphodiesters as GPR84 Antagonists with High Blood Exposure for the Treatment of Lung Inflammation. J Med Chem, 66 (8), 5820-5838. doi:10.1021/acs.jmedchem.3c00053
Li, X., Hanafusa, K., Kage, M., Yokoyama, N., Nakayama, H., Hotta, T., … Iwabuchi, K. (2021). Lysophosphatidylglucoside is a GPR55 -mediated chemotactic molecule for human monocytes and macrophages.Biochem Biophys Res Commun, 569 , 86-92. doi:10.1016/j.bbrc.2021.06.090
Liu, Y., Zhang, Q., Chen, L. H., Yang, H., Lu, W., Xie, X., & Nan, F. J. (2016). Design and Synthesis of 2-Alkylpyrimidine-4,6-diol and 6-Alkylpyridine-2,4-diol as Potent GPR84 Agonists. ACS Med Chem Lett, 7 (6), 579-583. doi:10.1021/acsmedchemlett.6b00025
Lu, E., & Cyster, J. G. (2019). G-protein coupled receptors and ligands that organize humoral immune responses. Immunol Rev, 289 (1), 158-172. doi:10.1111/imr.12743
Lu, E., Wolfreys, F. D., Muppidi, J. R., Xu, Y., & Cyster, J. G. (2019). S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8. Nature, 567 (7747), 244-248. doi:10.1038/s41586-019-1003-z
Lucy, D., Purvis, G. S. D., Zeboudj, L., Chatzopoulou, M., Recio, C., Bataille, C. J. R., … Russell, A. J. (2019). A Biased Agonist at Immunometabolic Receptor GPR84 Causes Distinct Functional Effects in Macrophages. ACS Chem Biol, 14 (9), 2055-2064. doi:10.1021/acschembio.9b00533
Luscombe, V. B., Lucy, D., Bataille, C. J. R., Russell, A. J., & Greaves, D. R. (2020). 20 Years an Orphan: Is GPR84 a Plausible Medium-Chain Fatty Acid-Sensing Receptor? DNA Cell Biol, 39 (11), 1926-1937. doi:10.1089/dna.2020.5846
Mahmud, Z. A., Jenkins, L., Ulven, T., Labéguère, F., Gosmini, R., De Vos, S., … Milligan, G. (2017). Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84.Sci Rep, 7 (1), 17953. doi:10.1038/s41598-017-18159-3
Mancini, S. J., Mahmud, Z. A., Jenkins, L., Bolognini, D., Newman, R., Barnes, M., … Milligan, G. (2019). On-target and off-target effects of novel orthosteric and allosteric activators of GPR84.Sci Rep, 9 (1), 1861. doi:10.1038/s41598-019-38539-1
Marlo, J. E., Niswender, C. M., Days, E. L., Bridges, T. M., Xiang, Y., Rodriguez, A. L., … Conn, P. J. (2009). Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity. Mol Pharmacol, 75 (3), 577-588. doi:10.1124/mol.108.052886
Marsango, S., Ward, R. J., Jenkins, L., Butcher, A. J., Al Mahmud, Z., Dwomoh, L., … Milligan, G. (2022). Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands. J Biol Chem, 298 (5), 101932. doi:10.1016/j.jbc.2022.101932
Mårtensson, J., Sundqvist, M., Manandhar, A., Ieremias, L., Zhang, L., Ulven, T., … Forsman, H. (2021). The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity.J Innate Immun, 13 (4), 242-256. doi:10.1159/000514887
Meng, Y., Zhang, J., Zhang, F., Ai, W., Zhu, X., Shu, G., … Wang, S. (2017). Lauric Acid Stimulates Mammary Gland Development of Pubertal Mice through Activation of GPR84 and PI3K/Akt Signaling Pathway. J Agric Food Chem, 65 (1), 95-103. doi:10.1021/acs.jafc.6b04878
Mikkelsen, R. B., Arora, T., Trošt, K., Dmytriyeva, O., Jensen, S. K., Meijnikman, A. S., … Bäckhed, F. (2022). Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration. iScience, 25 (12), 105683. doi:10.1016/j.isci.2022.105683
Moran, S. P., Xiang, Z., Doyle, C. A., Maksymetz, J., Lv, X., Faltin, S., … Conn, P. J. (2019). Biased M(1) receptor-positive allosteric modulators reveal role of phospholipase D in M(1)-dependent rodent cortical plasticity. Sci Signal, 12 (610)doi:10.1126/scisignal.aax2057
Morfa, C. J., Bassoni, D., Szabo, A., McAnally, D., Sharir, H., Hood, B. L., … Smith, L. H. (2018). A Pharmacochaperone-Based High-Throughput Screening Assay for the Discovery of Chemical Probes of Orphan Receptors. Assay Drug Dev Technol, 16 (7), 384-396. doi:10.1089/adt.2018.868
Müller, M. M., Lehmann, R., Klassert, T. E., Reifenstein, S., Conrad, T., Moore, C., … Slevogt, H. (2017). Global analysis of glycoproteins identifies markers of endotoxin tolerant monocytes and GPR84 as a modulator of TNFα expression. Sci Rep, 7 (1), 838. doi:10.1038/s41598-017-00828-y
Nakagawa, M., Schmitz, R., Xiao, W., Goldman, C. K., Xu, W., Yang, Y., … Staudt, L. M. (2014). Gain-of-function CCR4 mutations in adult T cell leukemia/lymphoma. J Exp Med, 211 (13), 2497-2505. doi:10.1084/jem.20140987
Nicol, L. S., Dawes, J. M., La Russa, F., Didangelos, A., Clark, A. K., Gentry, C., … McMahon, S. B. (2015). The role of G-protein receptor 84 in experimental neuropathic pain. J Neurosci, 35 (23), 8959-8969. doi:10.1523/jneurosci.3558-14.2015
Ocón, B., Pan, J., Dinh, T. T., Chen, W., Ballet, R., Bscheider, M., … Butcher, E. C. (2017). A Mucosal and Cutaneous Chemokine Ligand for the Lymphocyte Chemoattractant Receptor GPR15. Front Immunol, 8 , 1111. doi:10.3389/fimmu.2017.01111
Ohue-Kitano, R., Nonaka, H., Nishida, A., Masujima, Y., Takahashi, D., Ikeda, T., … Kimura, I. (2023). Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR84. JCI Insight, 8 (2)doi:10.1172/jci.insight.165469
Pandey, S., Kumari, P., Baidya, M., Kise, R., Cao, Y., Dwivedi-Agnihotri, H., … Shukla, A. K. (2021). Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors.Mol Cell, 81 (22), 4605-4621.e4611. doi:10.1016/j.molcel.2021.09.007
Park, J. W., Yoon, H. J., Kang, W. Y., Cho, S., Seong, S. J., Lee, H. W., … Kim, H. J. (2018). G protein-coupled receptor 84 controls osteoclastogenesis through inhibition of NF-κB and MAPK signaling pathways. J Cell Physiol, 233 (2), 1481-1489. doi:10.1002/jcp.26035
Peiris, M., Aktar, R., Reed, D., Cibert-Goton, V., Zdanaviciene, A., Halder, W., … Blackshaw, A. (2022). Decoy bypass for appetite suppression in obese adults: role of synergistic nutrient sensing receptors GPR84 and FFAR4 on colonic endocrine cells. Gut, 71 (5), 928-937. doi:10.1136/gutjnl-2020-323219
Peters, A., Rabe, P., Krumbholz, P., Kalwa, H., Kraft, R., Schöneberg, T., & Stäubert, C. (2020). Natural biased signaling of hydroxycarboxylic acid receptor 3 and G protein-coupled receptor 84.Cell Commun Signal, 18 (1), 31. doi:10.1186/s12964-020-0516-2
Peters, A., Rabe, P., Liebing, A. D., Krumbholz, P., Nordström, A., Jäger, E., … Stäubert, C. (2022). Hydroxycarboxylic acid receptor 3 and GPR84 - Two metabolite-sensing G protein-coupled receptors with opposing functions in innate immune cells. Pharmacol Res, 176 , 106047. doi:10.1016/j.phrs.2021.106047
Pillaiyar, T., Köse, M., Namasivayam, V., Sylvester, K., Borges, G., Thimm, D., … Müller, C. E. (2018). 6-(Ar)Alkylamino-Substituted Uracil Derivatives: Lipid Mimetics with Potent Activity at the Orphan G Protein-Coupled Receptor 84 (GPR84). ACS Omega, 3 (3), 3365-3383. doi:10.1021/acsomega.7b02092
Pillaiyar, T., Köse, M., Sylvester, K., Weighardt, H., Thimm, D., Borges, G., … Müller, C. E. (2017). Diindolylmethane Derivatives: Potent Agonists of the Immunostimulatory Orphan G Protein-Coupled Receptor GPR84. J Med Chem, 60 (9), 3636-3655. doi:10.1021/acs.jmedchem.6b01593
Puengel, T., De Vos, S., Hundertmark, J., Kohlhepp, M., Guldiken, N., Pujuguet, P., … Tacke, F. (2020). The Medium-Chain Fatty Acid Receptor GPR84 Mediates Myeloid Cell Infiltration Promoting Steatohepatitis and Fibrosis. J Clin Med, 9 (4)doi:10.3390/jcm9041140
Recio, C., Lucy, D., Purvis, G. S. D., Iveson, P., Zeboudj, L., Iqbal, A. J., … Greaves, D. R. (2018). Activation of the Immune-Metabolic Receptor GPR84 Enhances Inflammation and Phagocytosis in Macrophages. Front Immunol, 9 , 1419. doi:10.3389/fimmu.2018.01419
Reyes, A. W. B., Kim, H., Huy, T. X. N., Vu, S. H., Nguyen, T. T., Kang, C. K., … Kim, S. (2021). Immune-metabolic receptor GPR84 surrogate and endogenous agonists, 6-OAU and lauric acid, alter Brucella abortus 544 infection in both in vitro and in vivo systems. Microb Pathog, 158 , 105079. doi:10.1016/j.micpath.2021.105079
Rumianek, A. N., & Greaves, D. R. (2020). How Have Leukocyte In Vitro Chemotaxis Assays Shaped Our Ideas about Macrophage Migration?Biology (Basel), 9 (12)doi:10.3390/biology9120439
Sam, Q. H., Ling, H., Yew, W. S., Tan, Z., Ravikumar, S., Chang, M. W., & Chai, L. Y. A. (2021). The Divergent Immunomodulatory Effects of Short Chain Fatty Acids and Medium Chain Fatty Acids. Int J Mol Sci, 22 (12)doi:10.3390/ijms22126453
Schall, T. J., & Proudfoot, A. E. (2011). Overcoming hurdles in developing successful drugs targeting chemokine receptors. Nat Rev Immunol, 11 (5), 355-363. doi:10.1038/nri2972
Schiöth, H. B., & Fredriksson, R. (2005). The GRAFS classification system of G-protein coupled receptors in comparative perspective.Gen Comp Endocrinol, 142 (1-2), 94-101. doi:10.1016/j.ygcen.2004.12.018
Schulze, A. S., Kleinau, G., Krakowsky, R., Rochmann, D., Das, R., Worth, C. L., … Stäubert, C. (2022). Evolutionary analyses reveal immune cell receptor GPR84 as a conserved receptor for bacteria-derived molecules. iScience, 25 (10), 105087. doi:10.1016/j.isci.2022.105087
Strambu, I. R., Seemayer, C. A., Fagard, L. M. A., Ford, P. A., Van der Aa, T. A. K., de Haas-Amatsaleh, A. A., … Cottin, V. (2023). GLPG1205 for idiopathic pulmonary fibrosis: a phase 2 randomised placebo-controlled trial. Eur Respir J, 61 (3)doi:10.1183/13993003.01794-2022
Sundqvist, M., Christenson, K., Holdfeldt, A., Gabl, M., Mårtensson, J., Björkman, L., … Forsman, H. (2018). Similarities and differences between the responses induced in human phagocytes through activation of the medium chain fatty acid receptor GPR84 and the short chain fatty acid receptor FFA2R. Biochim Biophys Acta Mol Cell Res, 1865 (5), 695-708. doi:10.1016/j.bbamcr.2018.02.008
Suply, T., Hannedouche, S., Carte, N., Li, J., Grosshans, B., Schaefer, M., … Bassilana, F. (2017). A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia. Sci Signal, 10 (496)doi:10.1126/scisignal.aal0180
Suzuki, M., Takaishi, S., Nagasaki, M., Onozawa, Y., Iino, I., Maeda, H., … Oda, T. (2013). Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J Biol Chem, 288 (15), 10684-10691. doi:10.1074/jbc.M112.420042
Venkataraman, C., & Kuo, F. (2005). The G-protein coupled receptor, GPR84 regulates IL-4 production by T lymphocytes in response to CD3 crosslinking. Immunol Lett, 101 (2), 144-153. doi:10.1016/j.imlet.2005.05.010
Vermeire, S., Reinisch, W., Wasko-Czopnik, D., Van Kaem, T., Desrivot, J., Vanhoutte, F., & Beetens, J. (2017). P610 Efficacy and safety of GLPG1205, a GPR84 antagonist, in ulcerative colitis: multi-centre proof-of-concept study. Journal of Crohn’s and Colitis, 11 (suppl_1), S390-S391. doi:10.1093/ecco-jcc/jjx002.734
Wang, J., Wu, X., Simonavicius, N., Tian, H., & Ling, L. (2006). Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84. J Biol Chem, 281 (45), 34457-34464. doi:10.1074/jbc.M608019200
Wang, S. W., Zhang, Q., Lu, D., Fang, Y. C., Yan, X. C., Chen, J., … Xie, X. (2023). GPR84 regulates pulmonary inflammation by modulating neutrophil functions. Acta Pharmacol Sin , 1-11. doi:10.1038/s41401-023-01080-z
Wei, L., Tokizane, K., Konishi, H., Yu, H. R., & Kiyama, H. (2017). Agonists for G-protein-coupled receptor 84 (GPR84) alter cellular morphology and motility but do not induce pro-inflammatory responses in microglia. J Neuroinflammation, 14 (1), 198. doi:10.1186/s12974-017-0970-y
Wittenberger, T., Schaller, H. C., & Hellebrand, S. (2001). An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. J Mol Biol, 307 (3), 799-813. doi:10.1006/jmbi.2001.4520
Yen, Y. C., Schafer, C. T., Gustavsson, M., Eberle, S. A., Dominik, P. K., Deneka, D., … Handel, T. M. (2022). Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias. Sci Adv, 8 (28), eabn8063. doi:10.1126/sciadv.abn8063
Yin, C., Cheng, L., Pan, J., Chen, L., Xue, Q., Qin, J., … Ren, H. (2020). Regulatory role of Gpr84 in the switch of alveolar macrophages from CD11b(lo) to CD11b(hi) status during lung injury process. Mucosal Immunol, 13 (6), 892-907. doi:10.1038/s41385-020-0321-7
Yousefi, S., Cooper, P. R., Potter, S. L., Mueck, B., & Jarai, G. (2001). Cloning and expression analysis of a novel G-protein-coupled receptor selectively expressed on granulocytes. J Leukoc Biol, 69 (6), 1045-1052.
Zhang, Q., Chen, L. H., Yang, H., Fang, Y. C., Wang, S. W., Wang, M., … Xie, X. (2022). GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages.Acta Pharmacol Sin, 43 (8), 2042-2054. doi:10.1038/s41401-021-00825-y
Zhang, Q., Yang, H., Li, J., & Xie, X. (2016). Discovery and Characterization of a Novel Small-Molecule Agonist for Medium-Chain Free Fatty Acid Receptor G Protein-Coupled Receptor 84. J Pharmacol Exp Ther, 357 (2), 337-344. doi:10.1124/jpet.116.232033
Zidar, D. A., Violin, J. D., Whalen, E. J., & Lefkowitz, R. J. (2009). Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands. Proc Natl Acad Sci U S A, 106 (24), 9649-9654. doi:10.1073/pnas.0904361106