Main findings
In this cohort study, we found a strong and positive correlation between
early-pregnancy blood pressure and risks of preeclampsia. The absolute
risks of preeclampsia increased across the whole range of
maternal pre-pregnancy BMI, early pregnancy TG concentrations, and early
pregnancy blood pressure. Risks of preeclampsia increased significantly
within stage 1 or stage 2 hypertension, particularly among women
combined with both BMI ≥ 25 kg/m2 and a TG
concentration ≥ the 90th quartile. To the best of our
knowledge, this is the first study to raise the importance of
considering maternal metabolic risk factors such as overweight/obese and
high TG in risk prediction of preeclampsia and the necessity of
intervention should be conducted among women with stage 1/2 hypertension
under those circumstances.