Conclusion
In summary, our study found that elevated blood pressure, stage 1 and stage 2 hypertension diagnosed based on 2017 ACC/AHA criteria increase the risks of preeclampsia, especially the latter two. Obesity and elevated TG serum concentrations were two independent risk factors for developing preeclampsia (data not shown), and they tended to strengthen the association between the new BP categories and the risk of developing preeclampsia, especially in stage 1 and stage 2 hypertension. The results would add value to the clinical practice that clinicians should pay more attention and raise the necessity of intervention to women with stage 1/2 hypertension at <20 weeks gestation under the condition of overweight/obesity and high TG in identifying women at heightened risk for preeclampsia.
Author contributions: Drs Lin and Wu had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of its analysis.
Concept and design: Huang, Lin and Wu.
Acquisition, analysis and interpretation of data: All authors.
Drafting of the manuscript: Wu, Lin.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Wu, Lin and Wei.
Obtained funding: Huang, Lin and Wu.
Administrative, technical, or material support: Wu, Lin, Huang.
Supervision: Lin, Huang.
Conflict of interest disclosures: No disclosures to report.
Data sharing statement: The dataset generated from the study is available on request to the corresponding author.