Graphical abstract text
The dorsal subiculum is the primary source of hippocampal projections to the rat retrosplenial cortex. Disruption of the subiculum to retrosplenial projections impaired spatial working memory whenever the test variant created a conflict between cue-types, associated with a switch between different strategies. These findings suggest that the direct projections from the dorsal subiculum to the granular retrosplenial cortex help to maintain the flexible integration of different spatial cue-types.