Pre-surgery training, post-surgery baseline analyses, and non-infusion sessions
A series of independent t -tests considered whether there might be pre-surgery (Standard condition only) or post-operative training performance differences between the iDREADDs and GFP-control rats on the five T-maze task conditions prior to any infusions. The two groups did not differ significantly on the pre-surgery training nor on the baseline training prior to commencement of infusion trials for the five test conditions: all ts < 1.86, ps> 0.078. A further set of t -tests took the scores from the non-infusion sessions that were interleaved between the saline and clozapine sessions (Figure 1), for all but the Dark condition. Again, there were no performance differences between the iDREADDs and GFP-control animals on the infusion-free days for each of the four conditions: all ts < 1.01, ps> 0.29.