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\begin{document}

\title{Long non-coding RNA GAS5 rs145204276 indel polymorphism and cancer risk:
A systemic and meta-analysis review}



\author[1]{Arash Poursheikhani}%
\author[2]{Vahid Reza Askari}%
\author[3]{Eskandar Taghizadeh }%
\author[4]{Negin Nokhandani}%
\author[1]{Arash  Salmaninejad}%
\author[5]{Gordon A  Ferns}%
\author[1]{Alireza  Pasdar}%
\author[2]{Majid Ghayour-Mobarhan }%
\affil[1]{1-	Medical Genetics Research Centre, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran}%
\affil[2]{Mashhad University of Medical Sciences}%
\affil[3]{4-	Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran}%
\affil[4]{5-	Department of Medical Immunology, Faculty of Medicine, Golestan University of Medical Sciences, Golestan, Iran}%
\affil[5]{Brighton and Sussex Medical School}%


\vspace{-1em}



  
  \date{June 17, 2024}


\begingroup
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\selectlanguage{english}
\begin{abstract}
Introduction: Cancer is the second most common cause of death globally.
It has been demonstrated that long non-coding RNAs (lncRNAs) may play an
essential role in cancer development. The lncRNA growth arrest-special 5
(GAS5) is a critical tumor suppressor in many types of human cancers. We
have therefore conducted a meta-analysis to determine the association of
lncRNA GAS5 rs145204276 indel polymorphism and cancer risk. Methods: A
comprehensive literature search in PubMed, Scopus, and Web of Knowledge
were conducted up to July 1, 2019. Eligible studies were included in a
meta-analysis. All statistical analyses were conducted using the
Metagenyo online tool. Results: Our results showed no significant
association between the lncRNA GAS5 rs145204276 and cancer risk using
all genetic models. In subgroup analysis, the polymorphism demonstrated
a significant association with a lower risk of gastric cancer.
Sensitivity analysis confirmed the robustness of our results. No
publication bias was also identified. Conclusions: Although the lncRNA
GAS5 polymorphism is not associated with increased cancer risk, but its
polymorphism was associated with a reduced risk of gastric cancer in
subgroup analysis. Further studies with larger sample sizes across
different ethnicities need to be performed to explore the association's
strength.%
\end{abstract}%



\sloppy


\textbf{Long non-coding RNA \emph{GAS5} rs145204276 indel}

\textbf{polymorphism and cancer risk: A systemic and meta-analysis
review}

Arash Poursheikhani \textsuperscript{1, +}, Vahid Reza
Askari\textsuperscript{2, 3, +}, Eskandar Taghizadeh
\textsuperscript{4}, Negin Nokhandani \textsuperscript{5}, Arash
Salmaninejad\textsuperscript{1}, Gordon A Ferns \textsuperscript{7},
Alireza Pasdar \textsuperscript{1, 8, 9,} *, Majid
Ghayour-Mobarhan\textsuperscript{2, 6,} *

\begin{enumerate}
\tightlist
\item
  Medical Genetics Research Centre, Faculty of Medicine, Mashhad
  University of Medical Sciences, Mashhad, Iran.
\item
  International UNESCO Center for Health-Related Basic Sciences and
  Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
\item
  Student Research Committee, School of Medicine, Mashhad University of
  Medical Sciences, Mashhad, Iran
\item
  Cellular and Molecular Research Center, Yasuj University of Medical
  Sciences, Yasuj, Iran
\item
  Department of Medical Immunology, Faculty of Medicine, Golestan
  University of Medical Sciences, Golestan, Iran
\item
  Metabolic Syndrome Research Center, School of Medicine, Mashhad
  University of Medical Sciences, Mashhad, Iran
\item
  Department of Medical Education, Brighton and Sussex Medical School,
  Falmer, Brighton, UK.
\item
  Bioinformatics Research Group, Mashhad University of Medical Sciences,
  Mashhad, Iran
\item
  Division of Applied Medicine, Medical School, University of Aberdeen,
  Foresterhill, Aberdeen, UK
\end{enumerate}

\textsuperscript{+} These authors have equally contributed to this work.

* Correspondences:

\emph{Alireza Pasdar} : Department of Medical Genetics and Molecular
Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. E-mail:
a.pasdar@abdn.ac.uk, pasdara@mums.ac.ir

\emph{Majid Ghayour Mobarhan} : International UNESCO Center for
Health-Related Basic Sciences and Human Nutrition, Mashhad University of
Medical Sciences, Mashhad, Iran. E-mail: ghayourm@mums.ac.ir, Fax: +98
51 38411538, Tel: +98 51 38411538

\textbf{Running Head:} LncRNA \emph{GAS5} polymorphism and cancer risk



\textbf{Abstract}

\textbf{Introduction:} Cancer is the second most common cause of death
globally. It has been demonstrated that long non-coding RNAs (lncRNAs)
may play an essential role in cancer development. The lncRNA growth
arrest-special 5 (\emph{GAS5} ) is a critical tumor suppressor in many
types of human cancers. We have therefore conducted a meta-analysis to
determine the association of lncRNA \emph{GAS5} rs145204276 indel
polymorphism and cancer risk.

\textbf{Methods:} A comprehensive literature search in PubMed, Scopus,
and Web of Knowledge were conducted up to July 1, 2019. Eligible studies
were included in a meta-analysis. All statistical analyses were
conducted using the Metagenyo online tool.

\textbf{Results:} Our results showed no significant association between
the lncRNA \emph{GAS5} rs145204276 and cancer risk using all genetic
models. In subgroup analysis, the polymorphism demonstrated a
significant association with a lower risk of gastric cancer. Sensitivity
analysis confirmed the robustness of our results. No publication bias
was also identified.

\textbf{Conclusions:} Although the lncRNA \emph{GAS5} polymorphism is
not associated with increased cancer risk, but its polymorphism was
associated with a reduced risk of gastric cancer in subgroup analysis.
Further studies with larger sample sizes across different ethnicities
need to be performed to explore the association's strength.

\textbf{Keywords:} Long non-coding RNA, \emph{GAS5} , Polymorphism,
Cancer, Meta-analysis



\textbf{Introduction}

Cancer is the second most common cause of death worldwide. Cancer was
responsible for 8.8 million deaths in 2015. Almost 70\% of
cancer-related deaths occur in low- and middle-income countries (Siegel
et al., 2015). Several lifestyle risk factors, including high body mass
index, low fruit and vegetable intake, lack of physical activity, and
tobacco and alcohol consumption, account for nearly one-third of deaths
from cancer (Forouzanfar et al., 2016, Hoseini et al., 2014). The
economic impact of cancer is substantial and increasing (McGuire, 2016).

Various factors, including environmental and genetic factors, are among
the most common ones that contribute to cancer development. However, the
mechanisms underlying cancer pathogenesis remain largely unclear. Long
non-coding RNAs (lncRNAs) have been widely investigated among the
potential genetic factors. It has been proposed that they play a crucial
role in cancer progression, tumorigenesis, and the biological activity
of malignant tumors (Kong et al., 2014, Hu et al., 2015, Hosseini et
al., 2022). These single-stranded, non-coding RNAs are among the
significant regulators of gene expression, including oncogenes and tumor
suppressor genes, cell cycle, proliferation, differentiation, and
apoptosis (Bartonicek et al., 2016, Zhang et al., 2016, Chen et al.,
2012, Bhan and Mandal, 2014).

To date, several lncRNAs have been discovered in the human genome
(Brosnan and Voinnet, 2009, Rashidmayvan et al., 2022). Genetic
variants, specifically the single nucleotide polymorphisms (SNPs),
located in lncRNA genes have the potential to make a crucial impact on
lncRNA expression levels, processing, or on the secondary structure of
lncRNAs which results in cancer development and progression as well as
the alteration of drug responses (Cheetham et al., 2013, Ling et al.,
2015, Pan et al., 2016). Dysregulation in lncRNAs expression profile has
been demonstrated by high throughput analysis in many tumor cells (Gupta
et al., 2010, Schmidt et al., 2011, Yang et al., 2012). The lncRNA
growth arrest-special 5 (\emph{GAS5} ) is a critical tumor suppressor
lncRNA in many types of human cancers, located on chromosome 1q25.

A large body of evidence has shown that \emph{GAS5} is down-regulated in
multiple cancers, including breast cancer, osteosarcoma, colorectal
cancer, bladder cancer, prostate cancer, pancreatic cancer, lung cancer,
gastric cancer, glioma, hepatocellular carcinoma, cervical cancer and
pleural mesothelioma (Zheng et al., 2016, Li et al., 2017, Li et al.,
2018c, Guo et al., 2017). Several investigations have shown that
\emph{GAS5} has the potential to act as a biomarker for metastasis,
prognosis, and cancer susceptibility (Sun et al., 2014, Kong et al.,
2016, Tu et al., 2014). Previous studies have considered the possible
association of lncRNA \emph{GAS5} rs145204276 polymorphism with cancer
risk. It has been shown that this novel indel (insertion /deletion)
polymorphism in the promoter of lncRNA \emph{GAS5}could modulate
colorectal cancer risk through \emph{GAS5} expression (Kong et al.,
2016). However, there are some inconsistencies in the results among
different studies (Li et al., 2018c, Li et al., 2017, Tao et al., 2015,
Xu et al., 2018, Yuan et al., 2018, Zheng et al., 2016, Zhu et al.,
2017, Zhu et al., 2016, Tang et al., 2019). Hence, we conducted a
meta-analysis including recent eligible studies to evaluate the
association of lncRNA GAS5 rs145204276 polymorphism and cancer risk.

\textbf{Methods}

\textbf{Search strategy}

A comprehensive literature search in PubMed, Scopus, and Web of
Knowledge was conducted independently by the two first authors up to
July 1, 2019, using the following keywords: (cancer* OR neoplas* OR
carcinom* OR tumor* OR tumour* OR Malignan* OR Metasta* OR tumour*) AND
(\emph{GAS5} OR ''\emph{growth arrest-specific 5} '' OR \emph{GAS-5}
OR\emph{SNHG2} ) AND (mutation* OR polymorphism* OR allele* OR variant*
OR SNP* OR ''single nucleotide polymorphism*''). The search was limited
to English publications. Additionally, the reference lists of relevant
studies were hand-searched for further articles.

\textbf{Inclusion and exclusion criteria}

Eligible studies were included in this meta-analysis according to the
following criteria: (1) case-control studies, (2) Considering\emph{GAS5}
polymorphisms in cancer risk, and (3) Available genotype distribution
frequencies. Exclusion criteria were (1) non-human studies; (2)
Duplicate or overlapping studies (in this case, the study with a larger
sample size was included); (3) Not relevant to cancer or polymorphism.

\textbf{Data extraction}

Two authors (AP and NN) independently extracted the relevant data. The
extracted results were checked by a third author (ARP). The following
items were explored in eligible articles: author's first name,
publication's year, country, ethnicity, source of group, total number of
cases and controls, genotyping methods, cancer types, genotype
distribution frequencies, minor allele frequency (MAF) and P value for
Hardy-Weinberg equilibrium (HWE) in the control group. The quality of
the included studies was assessed by two authors independently according
to the modified Newcastle-Ottawa scale (NOS) (supplementary table S1).
The scores ranged from 0 (the lowest quality) to 10 points (the highest
quality) (Goto et al.). Each type of cancer, source of control, and
genotyping method with two or more related reports were included in the
subgroup analysis.

\textbf{Statistical analysis}

The association between \emph{GAS5} polymorphisms and cancer risk was
evaluated using odds ratio (OR) and 95\% confidence intervals (95\% CI).
For each SNP, seven genetic models were adopted: allelic model
(del\emph{vs.} ins), recessive model (del/del \emph{vs.} del/ins+
ins/ins), dominant model (del/del+ del/ins \emph{vs.} ins/ins),
over-dominant model (del/ins \emph{vs.} del/del+ ins/ins), homozygote
contrast model (del/del \emph{vs.} ins/ins), additive model (del/del
\emph{vs.}ins/del) and heterozygote contrast model (del/ins \emph{vs.}
ins/ins). The Hardy-Weinberg Equilibrium (HWE) was calculated based on
the control group's genotype distribution through the \emph{X}
\textsuperscript{2}test, where a p-value of \textless{}0.05 was
considered significant disequilibrium. Inter-study heterogeneity was
calculated using\emph{I\textsuperscript{2}} statistics. The fixed-effect
model was used when \emph{I\textsuperscript{2}} was less than 50\%
(absence of heterogeneity); otherwise, the random-effect model was
adopted. Sensitivity analysis was conducted stepwise, omitting one study
at a time to determine the robustness of the pooled odds ratio and the
stability of the results. Egger's linear regression and Begg's funnel
plot were used to determine publication bias. All statistical analyses
were performed using metagenyo online tool (Martorell-Marugan et al.,
2017). A p-value of \textless{}0.05 was considered as the statistically
significant threshold.

\textbf{Results}

\textbf{Characteristics of eligible studies}

Using the specified keywords, a total of 89 articles were identified.
Ten articles that met our inclusion criteria were included in the
quantitative synthesis (Figure. 1). The studies comprised a total of
6917 cases and 8977 controls with gastric cancer, cervical squamous cell
carcinoma, osteosarcoma, colorectal cancer, hepatocellular cancer,
glioma, breast cancer, and lung cancer. Three eligible studies had a
population-based design, and seven were hospital-based. All the studies
were performed in Asian populations. The data are summarized in Table 1.

\textbf{Quantitative data synthesis for rs145204276 indel}

\textbf{polymorphism}

The association between the lncRNA \emph{GAS5} rs145204276 indel
polymorphism and cancer risk is presented in Table 2. The pooled OR of
the ten relevant studies for different genetic models was elucidated.

There was no significant association between the lncRNA
\emph{GAS5}rs145204276 indel polymorphism with cancer risk under allelic
model (del\emph{vs.} ins) (OR: 0.98; 95\%CI: 0.8024; 1.1941; p:
0.83;\emph{I\textsuperscript{2}} : 94\%); a recessive model
(del/del\emph{vs.} del/ins+ ins/ins) (OR: 1.09; 95\%CI: 0.7822; 1.5251;
p: 0.60;\emph{I\textsuperscript{2}} : 88\%); a dominant model (del/del+
del/ins\emph{vs.} ins/ins) (OR: 0.95; 95\%CI: 0.7571; 1.2016; p:
0.69;\emph{I\textsuperscript{2}} : 92\%), an over-dominant model (
del/ins\emph{vs.} del/del+ ins/ins) (OR: 0.93; 95\%CI: 0.8199; 1.0549;
p: 0.26;\emph{I\textsuperscript{2}} : 71\%); a homozygote contrast model
(del/del\emph{vs.} ins/ins) (OR: 1.06; 95\%CI: 0.6964; 1.6162; p:
0.78;\emph{I\textsuperscript{2}} : 92\%); an additive model
(del/del\emph{vs.} ins/del) (OR: 1.15; 95\%CI: 0.9055; 1.4682; p:
0.25;\emph{I\textsuperscript{2}} : 74\%) and a heterozygote contrast
model (del/ins \emph{vs.} ins/ins) (OR: 0.94; 95\%CI: 0.7744; 1.1403; p:
0.53;\emph{I\textsuperscript{2}} : 87\%) (Figure 2).

Furthermore, in the subgroup analysis based on cancer types, the
rs145204276 indel polymorphism was associated with a lower risk of
gastric cancers in the population in different genetic models; allelic
model (del \emph{vs.} ins) (OR: 0.78; 95\%CI: 0.6916; 0.8701; p:
0.00;\emph{I\textsuperscript{2}} : 40\%); a recessive model
(del/del\emph{vs.} del/ins+ ins/ins) (OR: 0.73; 95\%CI: 0.5565; 0.9603;
p: 0.02;\emph{I\textsuperscript{2}} : 00\%); a dominant model (del/del+
del/ins\emph{vs.} ins/ins) (OR: 0.73; 95\%CI: 0.6278; 0.8404; p:
0.00;\emph{I\textsuperscript{2}} : 29\%); an over-dominant model (
del/ins\emph{vs} . del/del+ ins/ins) (OR: 0.79; 95\%CI: 0.6809; 0.9161;
p: 0.00;\emph{I\textsuperscript{2}} : 45\%); a homozygote contrast model
(del/del\emph{vs.} ins/ins) (OR: 0.64; 95\%CI: 0.4861; 0.8529; p:
0.00;\emph{I\textsuperscript{2}} : 38\%) and a heterozygote contrast
model (del/ins \emph{vs.} ins/ins) (OR: 0.75; 95\%CI: 0.6394; 0.8683; p:
0.00;\emph{I\textsuperscript{2}} : 40\%). Furthermore, in the subgroup
analysis based on the source of control, we did not find any significant
association between the polymorphism and the subgroup investigations
(Table 2).

\textbf{Test of heterogeneity for rs145204276 indel polymorphism}

For lncRNA \emph{GAS5} rs145204276 indel polymorphism, significant
heterogeneity was shown after pooling the data in all genetic models.
The heterogeneities remained even in subgroup analysis based on the
source of control. Moreover, the heterogeneities were removed when
subgroup analysis was conducted based on cancer type. The data are
listed in Table 2.

\textbf{Sensitivity analysis}

Sensitivity analyses illustrated that omitting any single study, one at
a time, did not influence the pooled OR of different genetic models of
our meta-analysis results. This analysis proposed that our results were
stable in different genetic models and that our study was robust (Figure
3).

\textbf{Publication bias}

Potential publication bias was assessed using Egger's linear regression
and Begg's funnel plot. No significant publication bias was presented in
all of the different genetic models for the lncRNA
\emph{GAS5}rs145204276 indel polymorphism (p\textgreater{}0.05) (Table 2
and figure 4).

\textbf{Discussion}

Recent evidence has shown that 98\% of the human genome could be
transcribed into non-coding RNAs (Tao et al., 2015). A large body of
studies emphasizes the potential functional roles of lncRNAs in various
biological mechanisms and tumorigenesis (Yan et al., 2017, Kong et al.,
2016). Altered and aberrant expression of lncRNAs in numerous tumor
samples has been well documented, which drives several putative
carcinogenesis mechanisms (Li et al., 2018a, Li et al., 2018c, Yan et
al., 2017). The lncRNA \emph{GAS5}plays a vital role as a tumor
suppressor lncRNA in almost all cancers (Zheng et al., 2016, Li et al.,
2017, Li et al., 2018c, Guo et al., 2017). LncRNA \emph{GAS5}also
encodes small nucleolar RNAs (snoRNAs) and acts as a glucocorticoid
riborepressor. Previous investigations have shown that
\emph{GAS5}overexpression inhibits osteosarcoma's tumorigenesis and
epithelial-mesenchymal transition (EMT) by regulating the miR-221/ARHI
pathway (Smith and Steitz, 1998, Xu et al., 2018). There is substantial
literature reporting clinical cancer therapy approaches for
lncRNA\emph{GAS5} . Several reports have shown a down-regulation of
\emph{GAS5}in various cancer cells, associated with a poorer prognosis
(Cao et al., 2014, Kong et al., 2016, Mourtada-Maarabouni et al., 2009,
Li et al., 2018a). Whereas it has been demonstrated the upregulation of
\emph{GAS5} is associated with a more promising outcome in prostate
cancer therapy (Yan et al., 2017). It has been demonstrated that
\emph{GAS5} can inhibit cell growth by sponging\emph{miR-21,} which
results in the upregulation of \emph{phosphatase and tensin homologs}
(\emph{PTEN} ) and inhibition of the mTOR signaling pathway in
trastuzumab-resistant HER2-positive breast cancer (Oldoni et al., 2016).
Furthermore, the downregulation of lncRNA \emph{GAS5} confers tamoxifen
resistance by activating miR-222, which targets \emph{PTEN} in breast
cancer (Gu et al., 2018).

The underlying mechanisms of lncRNA \emph{GAS5} are not fully
understood. Numerous investigations have reported that polymorphisms in
lncRNA might have a crucial impact on the lncRNA functions (Kong et al.,
2016). Current evidence has shown that lncRNA \emph{GAS5} rs145204276
polymorphism could predispose patients to cancer. However, the results
concerning the association of the lncRNA \emph{GAS5} rs145204276
polymorphism and cancer risk have been inconsistent (Li et al., 2018c,
Li et al., 2017, Tao et al., 2015, Xu et al., 2018, Yuan et al., 2018,
Zheng et al., 2016, Zhu et al., 2017, Zhu et al., 2016). For instance,
Zhu\emph{et al.} showed that the del allele elevated colorectal cancer
risk in the patients (Zhu et al., 2016). At the same time, Zheng
\emph{et al.} found that the del allele was significantly associated
with decreased colorectal cancer risk (Zheng et al., 2016). In addition,
previous studies have indicated that the lncRNA \emph{GAS5} rs145204276
polymorphism could reduce the risk of gastric cancer (Aminian et al.,
2019, Li et al., 2018b). Different factors, including variation in
populations and ethnicity, different cancer types or lack of statistical
power, could cause this discrepancy. Therefore, we conducted this
meta-analysis by ten eligible studies, including 6917 cases and 8977
controls, to increase the strength of assessing the association of the
lncRNA \emph{GAS5} rs145204276 polymorphism and cancer risk. To the best
of our knowledge, this meta-analysis is the first meta-analysis which
systematically considers all eligible studies in the association of the
lncRNA \emph{GAS5} rs145204276 polymorphism with cancer risk. In this
study, we did not find any significant association between the lncRNA
\emph{GAS5} rs145204276 polymorphism with cancer risk in the different
genetic models. Interestingly, in subgroup analysis based on cancer
types, we found that the polymorphism was associated with decreased
gastric cancer risk in the patients. It has been demonstrated that the
lncRNA \emph{GAS5} rs145204276 del allele positively correlated to
P27Kip\textsuperscript{1} expression in gastric cancer patients (Aminian
et al., 2019). Besides, P27Kip\textsuperscript{1} has been shown to act
as a tumor suppressor gene, and its down regulation has been reported in
various cancers (Ogino et al., 2009, Zhuang et al., 2011).

However, in subgroup analysis based on the source of control, the data
did not show a significant association between the polymorphism and
cancer risk. Sensitivity analyses revealed that the results were stable
and robust among the different genetic models. No publication bias was
found in the meta-analysis. In fact, it indicates that our meta-analysis
is reliable. However, this meta-analysis has some limitations. These
limitations may be a guide for future studies to overcome them. First,
only studies written in English were included. Second, the subgroup
analysis was limited to cancer types and sources of control. We did not
consider an analysis of other variables such as lifestyle factors (e.g.,
smoking, exercise, and alcohol consumption), environmental factors,
gender, stage of cancer, metastasis, and chemotherapy response due to
inadequate and inaccessible data of the eligible articles. Third, the
sample sizes of the studies were relatively small, which could have a
dramatic impact on the power of the study. Fourth, there was
heterogeneity in our pooled results which may originate from different
types of cancers. All of the included population samples were from
China. Finally, genotyping errors may be possible due to applying other
genotyping methods. Hence, it is necessary to conduct further studies in
different ethnicities with large sample sizes and consider more
comprehensive criteria for assessing lncRNA \emph{GAS5} and cancer
risks.

\textbf{Conclusion}

We have shown that the lncRNA \emph{GAS5} rs145204276 polymorphism was
not significantly associated with an overall increase in cancer risk.
Next, in subgroup analysis, lncRNA \emph{GAS5} rs145204276 polymorphism
was associated with decreased gastric cancer risk. Our results were
stable and reliable, representative of the Asian population.

\textbf{Declarations}

\textbf{Ethics approval and consent to participate}

Not applicable. It is a systematic and meta-analysis review article.

\textbf{Consent to publish}

All authors read and had consent for publication.

\textbf{Availability of data and materials}

The data supporting this study's findings are available from the
corresponding author upon reasonable request.

\textbf{Competing interests}

The authors declare no conflict of interest.

\textbf{Funding}

Not applicable

\textbf{Authors' Contributions}

We declare that we contributed significantly towards the research study
i.e., (a) conception, design and/or analysis and interpretation of data
and to (b) drafting the article or revising it critically for important
intellectual content and on (c) final approval of the version to be
published.

\textbf{Acknowledgment:}

This work was supported by Mashhad University of Medical Sciences,
Mashhad, Iran.



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Table 1: Characteristics of the eligible studies included in the
meta-analysis.\selectlanguage{english}
\begin{longtable}[]{@{}llllllllllllllllll@{}}
\toprule
\begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
First Author\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Year\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Country\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Ethnicity\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
source of control\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
case\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
control\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Genotype Frequency\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Genotype Frequency\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Genotype Frequency\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Genotype Frequency\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Genotyping methods\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
HWE\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
MAF\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
Type of Cancers\strut
\end{minipage} & \begin{minipage}[b]{0.05\columnwidth}\raggedright\strut
NOS\strut
\end{minipage}\tabularnewline
\midrule
\endhead
\begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
ins/ins case\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
ins/del case\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
del/del case\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
ins/ins control\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
ins/del control\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
del/del control\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Tao R\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
2015\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
China\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Asian\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
PB\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
1034\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
1054\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
414\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
480\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
140\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
504\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
468\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
82\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
AS-PCR\textsuperscript{3}\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
0.06\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
0.30\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
HCC\textsuperscript{1}\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
10\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Zheng Y\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
2016\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
China\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Asian\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
HB\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
1400\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
1400\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
738\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
550\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
112\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
639\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
610\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
151\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
AS-PCR\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
0.76\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
0.33\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Colorectal\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
7\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Zhu Z\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
2016\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
China\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Asian\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
HB\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
813\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
926\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
317\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
387\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
109\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
444\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
409\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
73\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
AS-PCR\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
0.11\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
0.30\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Colorectal\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
7\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Li Q\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
2017\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
China\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Asian\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
PB\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
1253\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
1354\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
682\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
483\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
88\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
638\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
593\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
123\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
TaqMan\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
0.37\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
0.31\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Gastric\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
9\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Li W\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
2017\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
China\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Asian\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
PB\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
600\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
600\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
287\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
270\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
43\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
246\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
292\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
62\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
AS-PCR\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
0.07\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
0.35\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Lung\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
8\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Zhu Z\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
2017\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
China\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Asian\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
HB\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
920\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
1018\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
364\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
433\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
123\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
486\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
459\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
73\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
AS-PCR\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
0.01\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
0.30\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
CSCC\textsuperscript{2}\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
6\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Xu L\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
2018\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
China\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Asian\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
HB\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
132\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
1270\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
80\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
42\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
10\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
616\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
543\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
111\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
AS-PCR\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
0.57\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
0.30\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Osteosarcoma\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
8\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Yuan j\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
2018\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
China\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Asian\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
HB\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
404\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
820\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
154\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
198\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
52\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
419\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
346\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
55\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Mass array\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
0.14\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
0.28\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Glioma\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
9\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Tang Y\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
2018\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
China\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Asian\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
HB\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
575\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
602\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
310\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
220\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
45\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
279\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
261\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
62\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
AS-PCR\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
0.99\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
0.32\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Breast\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
9\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Aminian K\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
2018\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Iran\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Asian\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
HB\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
130\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
230\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
88\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
36\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
6\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
126\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
84\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
20\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
AS-PCR\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
0.27\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
0.27\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
Gastric\strut
\end{minipage} & \begin{minipage}[t]{0.03\columnwidth}\raggedright\strut
7\strut
\end{minipage}\tabularnewline
\bottomrule
\end{longtable}

\textsuperscript{1}Hepatocellular carcinoma

\textsuperscript{2}Cervical squamous cell carcinoma

\textsuperscript{3}Allele specific- PCR

Table 2: Summary of the meta-analysis of the lncRNA
\emph{GAS5}rs145204276 indel polymorphism and cancer risk.\selectlanguage{english}
\begin{longtable}[]{@{}lllllllll@{}}
\toprule
\begin{minipage}[b]{0.11\columnwidth}\raggedright\strut
\textbf{Model}\strut
\end{minipage} & \begin{minipage}[b]{0.11\columnwidth}\raggedright\strut
\textbf{Number} \textbf{of studies}\strut
\end{minipage} & \begin{minipage}[b]{0.11\columnwidth}\raggedright\strut
\textbf{Test of association}\strut
\end{minipage} & \begin{minipage}[b]{0.11\columnwidth}\raggedright\strut
\textbf{Test of association}\strut
\end{minipage} & \begin{minipage}[b]{0.11\columnwidth}\raggedright\strut
\textbf{Test of association}\strut
\end{minipage} & \begin{minipage}[b]{0.11\columnwidth}\raggedright\strut
\textbf{Test of association}\strut
\end{minipage} & \begin{minipage}[b]{0.11\columnwidth}\raggedright\strut
\textbf{Test of heterogeneity}\strut
\end{minipage} & \begin{minipage}[b]{0.11\columnwidth}\raggedright\strut
\textbf{Test of heterogeneity}\strut
\end{minipage} & \begin{minipage}[b]{0.11\columnwidth}\raggedright\strut
\textbf{Publication bias}\strut
\end{minipage}\tabularnewline
\midrule
\endhead
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{OR}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{95\% CI}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
p-val\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Model}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
p-val\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
I\textsuperscript{2}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\emph{p-val} \textbf{(Egger's test)}\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Allelic model (del \emph{vs.} ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Allelic model (del \emph{vs.} ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Allelic model (del \emph{vs.} ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Overall\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
10\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.98\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.8024; 1.1941{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.83\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.94\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.62\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Type of cancer\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Colorectal\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
2\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
1.04\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.6035; 1.8090{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.88\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.97\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
NA\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Gastric\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
2\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{0.78}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{{[}0.6916; 0.8701{]}}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Fixed\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.20\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.40\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
NA\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Source of control\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
HB\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
7\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.99\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.7614; 1.2833{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.93\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.94\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.62\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
PB\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
3\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.95\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.6606; 1.3705{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.79\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.95\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.87\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Recessive model (del/del \emph{vs.} del/ins+ ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Recessive model (del/del \emph{vs.} del/ins+ ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Recessive model (del/del \emph{vs.} del/ins+ ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Recessive model (del/del \emph{vs.} del/ins+ ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Recessive model (del/del \emph{vs.} del/ins+ ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Overall\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
10\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
1.09\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.7822; 1.5251{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.60\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.88\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.65\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Type of cancer\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Colorectal\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
2\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
1.14\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.4599; 2.8040{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.78\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.95\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
NA\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Gastric\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
2\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{0.73}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{{[}0.5565; 0.9603{]}}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.02\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Fixed\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.43\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
NA\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Source of control\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
HB\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
7\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
1.14\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.7453; 1.7457{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.54\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.88\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.75\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
PB\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
3\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.99\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.5133; 1.8995{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.97\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.92\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.69\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Dominant model (del/del+ del/ins \emph{vs.} ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Dominant model (del/del+ del/ins \emph{vs.} ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Dominant model (del/del+ del/ins \emph{vs.} ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Dominant model (del/del+ del/ins \emph{vs.} ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Dominant model (del/del+ del/ins \emph{vs.} ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Overall\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
10\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.95\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.7571; 1.2016{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.69\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.92\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.74\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Type of cancer\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Colorectal\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
2\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
1.04\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.5500; 1.9623{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.91\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.96\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
NA\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Gastric\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
2\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{0.73}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{{[}0.6278; 0.8404{]}}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Fixed\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.29\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.09\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
NA\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Source of control\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
HB\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
7\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.97\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.7099; 1.3132{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.82\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.92\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.68\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
PB\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
3\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.92\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.6108; 1.3874{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.69\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.93\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.97\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Over-dominant model ( del/ins \emph{vs.} del/del+
ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Over-dominant model ( del/ins \emph{vs.} del/del+
ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Over-dominant model ( del/ins \emph{vs.} del/del+
ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Over-dominant model ( del/ins \emph{vs.} del/del+
ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Over-dominant model ( del/ins \emph{vs.} del/del+
ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Over-dominant model ( del/ins \emph{vs.} del/del+
ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Overall\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
10\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.93\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.8199; 1.0549{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.26\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.71\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.53\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Type of cancer\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Colorectal\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
2\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.98\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.7166; 1.3284{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.88\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.01\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.85\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
NA\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Gastric\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
2\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{0.79}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{{[}0.6809; 0.9161{]}}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Fixed\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.45\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
NA\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Source of control\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
HB\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
7\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.93\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.7830; 1.1127{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.44\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.75\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.47\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
PB\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
3\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.91\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.7521; 1.1032{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.34\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.04\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.70\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.95\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Homozygote contrast model (del/del \emph{vs.} ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Homozygote contrast model (del/del \emph{vs.} ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Homozygote contrast model (del/del \emph{vs.} ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Homozygote contrast model (del/del \emph{vs.} ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Homozygote contrast model (del/del \emph{vs.} ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Overall\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
10\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
1.06\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.6964; 1.6162{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.78\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.92\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.68\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Type of cancer\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Colorectal\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
2\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
1.15\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.3629; 3.6704{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.81\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.97\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
NA\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Gastric\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
2\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{0.64}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{{[}0.4861; 0.8529{]}}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Fixed\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.38\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
NA\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Source of control\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
HB\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
7\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
1.11\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.6484; 1.9116{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.70\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.92\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.76\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
PB\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
3\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.94\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.4190; 2.1301{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.89\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.94\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.74\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Additive model (del/del \emph{vs.} ins/del)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Additive model (del/del \emph{vs.} ins/del)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Additive model (del/del \emph{vs.} ins/del)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Additive model (del/del \emph{vs.} ins/del)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Overall\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
10\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
1.15\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.9055; 1.4682{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.25\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.74\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.74\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Type of cancer\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Colorectal\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
2\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
1.13\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.5977; 2.1423{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.70\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.89\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
NA\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Gastric\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
2\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.86\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.6475; 1.1475{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.31\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Fixed\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.67\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
NA\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Source of control\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
HB\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
7\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
1.21\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.8941; 1.6358{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.22\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.73\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.87\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
PB\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
3\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
1.04\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.6414; 1.6999{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.86\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.84\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.64\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Heterozygote contrast model (del/ins \emph{vs.} ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Heterozygote contrast model (del/ins \emph{vs.} ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Heterozygote contrast model (del/ins \emph{vs.} ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Heterozygote contrast model (del/ins \emph{vs.} ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{Heterozygote contrast model (del/ins \emph{vs.} ins/ins)}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Overall\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
10\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.94\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.7744; 1.1403{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.53\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.87\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.69\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Type of cancer\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Colorectal\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
2\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
1.01\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.6033; 1.7019{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.96\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.94\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
NA\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Gastric\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
2\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{0.75}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\textbf{{[}0.6394; 0.8683{]}}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Fixed\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.40\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
NA\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Source of control\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
HB\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
7\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.95\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.7299; 1.2315{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.69\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.88\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.62\strut
\end{minipage}\tabularnewline
\begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
PB\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
3\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.91\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
{[}0.6576; 1.2645{]}\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.58\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
Random\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.00\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
0.89\strut
\end{minipage} & \begin{minipage}[t]{0.08\columnwidth}\raggedright\strut
1.00\strut
\end{minipage}\tabularnewline
\bottomrule
\end{longtable}

Supplementary

Table S1: Modified Newcastle-Ottawa scale for quality assessment of the
studies.\selectlanguage{english}
\begin{longtable}[]{@{}lll@{}}
\toprule
\textbf{Quality score assessment} & \textbf{Quality score assessment} &
\textbf{score}\tabularnewline
\midrule
\endhead
\textbf{Representativeness of cases} & \textbf{Representativeness of
cases} &\tabularnewline
& Consecutive/randomly selected form case population with a clearly
defined sampling frame & 2\tabularnewline
& Consecutive/randomly selected form case population without a clearly
defined sampling frame or with extensive & 1\tabularnewline
& Not described & 0\tabularnewline
\textbf{Source of controls} & \textbf{Source of controls}
&\tabularnewline
& Population- or Healthy-based & 2\tabularnewline
& Hospital-bases & 1\tabularnewline
& Not described & 0\tabularnewline
\textbf{Hardy-Weinberg equilibrium in controls} & \textbf{Hardy-Weinberg
equilibrium in controls} &\tabularnewline
& Hardy-Weinberg equilibrium & 2\tabularnewline
& Hardy-Weinberg disequilibrium & 1\tabularnewline
& Not available & 0\tabularnewline
\textbf{Genotyping examination} & \textbf{Genotyping examination}
&\tabularnewline
& Genotyping done under ''blinded'' condition and repeated again &
2\tabularnewline
& Genotyping done under ''blinded'' condition or repeated again &
1\tabularnewline
& Un-blinded done or not mentioned and unrepeated & 0\tabularnewline
\textbf{Association assessment} & \textbf{Association assessment}
&\tabularnewline
& Assess association between genotypes and cancer with appropriate
statistics and adjustment for confounders & 2\tabularnewline
& Assess association between genotypes and cancer with appropriate
statistics and without adjustment for confounders & 1\tabularnewline
& Inappropriate statistics used & 0\tabularnewline
\textbf{Total Score} & \textbf{Total Score} & 10\tabularnewline
\bottomrule
\end{longtable}

\textbf{Figure legends}

\textbf{Figure 1.} The flow diagram of the eligible studies selection.

\textbf{Figure 2.} Forest plots for the meta-analysis of
lncRNA\emph{GAS5} rs145204276 indel polymorphism and cancer risk. A.
Allelic model (del vs. ins). B. Recessive model (del/del vs. del/ins+
ins/ins). C. Dominant model (del/del+ del/ins vs. ins/ins). D.
Over-dominant model (del/ins vs. del/del+ ins/ins). E. Homozygote
contrast model (del/del vs. ins/ins). F. Additive model (del/del vs.
ins/del). G. Heterozygote contrast model (del/ins vs. ins/ins).

\textbf{Figure 3.} Forest plots for the sensitivity analysis of
lncRNA\emph{GAS5} rs145204276 polymorphism and cancer risk. A. Allelic
model (del vs. ins). B. Recessive model (del/del vs. del/ins+ ins/ins).
C. Dominant model (del/del+ del/ins vs. ins/ins). D. Over-dominant model
(del/ins vs. del/del+ ins/ins). E. Homozygote contrast model (del/del
vs. ins/ins). F. Additive model (del/del vs. ins/del). G. Heterozygote
contrast model (del/ins vs. ins/ins).

\textbf{Figure 4.} Funnel plots for the publication bias of
lncRNA\emph{GAS5} rs145204276 polymorphism and cancer risk. A. Allelic
model (del vs. ins). B. Recessive model (del/del vs. del/ins+ ins/ins).
C. Dominant model (del/del+ del/ins vs. ins/ins). D. Over-dominant model
(del/ins vs. del/del+ ins/ins). E. Homozygote contrast model (del/del
vs. ins/ins). F. Additive model (del/del vs. ins/del). G. Heterozygote
contrast model (del/ins vs. ins/ins).

\textbf{Figure. 1}\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/image1/image1}

\end{center}
\end{figure}

\textbf{Figure.} \textbf{2}\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/image2/image2}

\end{center}
\end{figure}

\textbf{Figure.} \textbf{3}\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/image3/image3}

\end{center}
\end{figure}

\textbf{Figure} . \textbf{4}\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/image4/image4}

\end{center}
\end{figure}

\selectlanguage{english}
\FloatBarrier
\end{document}

