Lysine is a Potential
Antidote for Paraquat Poisoning Induced Pulmonary Fibrosis
Wenyu Yang1, Xiaoxiao Meng1, Yong
Zhu1, Xinrun Ma2, Zhuoran
Cao2, Mengmeng Wang1, Wentao
Dai3, Yiming Tao4, Xiangdong
Jian4, Rui Tian1*, Zhengfeng
Yang1,2*, Ruilan Wang1*
1 Department of Critical Care Medicine, Shanghai
General Hospital, Shanghai Jiaotong University, School of Medicine,
Shanghai 201620, China
2 Precision Research Center for Refractory Diseases,
Institute for clinical Research, Shanghai General Hospital, Shanghai
Jiaotong University, School of Medicine, Shanghai 201620, China
3 Shanghai-MOST Key Laboratory of Health and Disease
Genomics & NHC Key Laboratory of Reproduction Regulation, Shanghai
Institute for Biomedical and Pharmaceutical Technologies (SIBPT), Fudan
University, Shanghai, 200080, China
4 Department of Poisoning and Occupational Diseases,
Emergency, Qilu Hospital, Cheeloo College of Medicine, Shandong
University, Jinan, Shandong, 250012, China
W.Y., X.M., Y.Z. and X.M. contributed equally to this work.
* To whom correspondence should be addressed:
Rui Tian, M.D.
Department of Critical Care Medicine
Shanghai General Hospital
650 Xinsongjiang Road,
Shanghai 201620, China
Email: thunder021@hotmail.com
Zhengfeng Yang, Ph.D.
Precision Research Center for Refractory Diseases
Institute for clinical Research
Shanghai General Hospital
650 Xinsongjiang Road,
Shanghai 201620, China
Email:Zhengfeng.yang@shgh.cn
Ruilan Wang, M.D.
Department of Critical Care Medicine
Shanghai General Hospital
650 Xinsongjiang Road,
Shanghai 201620, China
Email: wangyusun@hotmail.com
Key Words: Paraquat, pulmonary fibrosis, Lysine, STIM1, EMT,
Calcium
Data Availability Statement: The data that support the findings
of this study are available from the corresponding author upon
reasonable request. Some data may not be made available because of
privacy or ethical restrictions.