Key Results
Lysine treatment significantly reduces PQ-raised STIM1-TRPC1 association, excessive calcium influx, and thus EMT in AT II cells. As a result, lysine treatment strikingly decreases the mortality of PQ-poisoned mice, with a fully recovery of PQ-induced PF. Immune cells activation, largely occurred accompanied with epithelial damages and PF, are almost normalized with lysine treatment in PQ-poisoned cynomolgus model. A negative correlation between the blood calcium levels and the prognosis were observed in PQ-poisoned patients.