Figure 3. Lysine is an efficient antidote for PQ poisoning. (A-B) Daily weight change of PQ-poisoned mice treated w/wo lysine for 14 days. Mean ± s.d., *P < 0.05; Two-Way ANOVA. n = 8 in each group. (C) Kaplan-Meier analysis of survival rate in PQ-poisoned mice treated w/wo lysine. n = 8 initially in each group.(D) ELISA analysis of hydroxyproline in PQ-poisoned lungs treated w/wo lysine for 3 days. Mean ± s.d., **P < 0.01, ***P < 0.001; Two-Way ANOVA. N.S., not significant. (E) HE staining and Masson staining of PQ-poisoned lungs treated w/wo lysine for 3 days. Images are representative of more than three mice in each group. (F-H) Levels of serum biochemical parameters, including ALT (F), AST (G), and Creatinine (H) in PQ-poisoned mice treated w/wo lysine for 3 days. (I) Amino acid metabolic profiles measurement in plasma from healthy volunteers (n = 6) or PQ-poisoned patients (n = 7). Mean ± s.d., *P < 0.05; unpaired two–tailed Student’s t–test .