Figure 5. Blood calcium levels are negatively correlated with the severity of PQ poisoning. (A-B) A retrospective analysis of the correlation between PQ and blood calcium levels. (A) Mean ± s.d., ***P < 0.001; unpaired two–tailed Student’s t–test. n = 22 in healthy group, n= 18 in PQ group. (B) Pearson correlation coefficient. n = 22. (C-E) The correlation between PQ and levels of blood potassium (K+, C), sodium (Na+, D) or chloride (Cl-, E). (F&G) Analysis of blood calcium levels and blood creatinine levels in each PQ-poisoned patient during disease progression. (H) Levels of serum calcium levels in PQ-poisoned mice treated w/wo lysine for 3 days. (I)Levels of blood calcium in PQ-poisoned cynomolgus monkey treated w/wo lysine for 3 days. Arrows indicate lysine treatment.