Figure 3. Lysine is an efficient antidote for PQ poisoning.
(A-B) Daily weight change of PQ-poisoned mice treated w/wo lysine for
14 days. Mean ± s.d., *P < 0.05; Two-Way ANOVA. n = 8 in each
group. (C) Kaplan-Meier analysis of survival rate in
PQ-poisoned mice treated w/wo lysine. n = 8 initially in each group.(D) ELISA analysis of hydroxyproline in PQ-poisoned lungs
treated w/wo lysine for 3 days. Mean ± s.d., **P < 0.01, ***P
< 0.001; Two-Way ANOVA. N.S., not significant. (E) HE
staining and Masson staining of PQ-poisoned lungs treated w/wo lysine
for 3 days. Images are representative of more than three mice in each
group. (F-H) Levels of serum biochemical parameters, including
ALT (F), AST (G), and Creatinine (H) in PQ-poisoned mice treated w/wo
lysine for 3 days. (I) Amino acid metabolic profiles
measurement in plasma from healthy
volunteers (n = 6) or PQ-poisoned patients (n = 7). Mean ± s.d., *P
< 0.05; unpaired two–tailed Student’s t–test .