Introduction
Measurement of glomerular filtration rates (GFRs) prior to hematopoietic
stem cell transplantation (SCT) is of the utmost importance. Regimen
choices and study eligibility are restricted by minimum baseline rates,
and it has been well demonstrated that pediatric patients who have a low
GFR prior to SCT have an increased risk of acute kidney injury (AKI),
chronic kidney disease (CKD), and death1,2Hyperfiltration, in which the GFR is abnormally elevated, is known to
occur in pediatric oncology and hematopoietic stem cell transplant (SCT)
patients. However there are no studies looking at the implications of
pre-SCT hyperfiltration on outcomes.3–5 We
hypothesized that pre-SCT hyperfiltration is a risk factor for AKI, CKD,
and mortality in pediatric patients.