\documentclass[10pt]{article}

\usepackage{fullpage}
\usepackage{setspace}
\usepackage{parskip}
\usepackage{titlesec}
\usepackage[section]{placeins}
\usepackage{xcolor}
\usepackage{breakcites}
\usepackage{lineno}
\usepackage{hyphenat}





\PassOptionsToPackage{hyphens}{url}
\usepackage[colorlinks = true,
            linkcolor = blue,
            urlcolor  = blue,
            citecolor = blue,
            anchorcolor = blue]{hyperref}
\usepackage{etoolbox}
\makeatletter
\patchcmd\@combinedblfloats{\box\@outputbox}{\unvbox\@outputbox}{}{%
  \errmessage{\noexpand\@combinedblfloats could not be patched}%
}%
\makeatother


\usepackage{natbib}




\renewenvironment{abstract}
  {{\bfseries\noindent{\abstractname}\par\nobreak}\footnotesize}
  {\bigskip}

\titlespacing{\section}{0pt}{*3}{*1}
\titlespacing{\subsection}{0pt}{*2}{*0.5}
\titlespacing{\subsubsection}{0pt}{*1.5}{0pt}


\usepackage{authblk}


\usepackage{graphicx}
\usepackage[space]{grffile}
\usepackage{latexsym}
\usepackage{textcomp}
\usepackage{longtable}
\usepackage{tabulary}
\usepackage{booktabs,array,multirow}
\usepackage{amsfonts,amsmath,amssymb}
\providecommand\citet{\cite}
\providecommand\citep{\cite}
\providecommand\citealt{\cite}
% You can conditionalize code for latexml or normal latex using this.
\newif\iflatexml\latexmlfalse
\providecommand{\tightlist}{\setlength{\itemsep}{0pt}\setlength{\parskip}{0pt}}%

\AtBeginDocument{\DeclareGraphicsExtensions{.pdf,.PDF,.eps,.EPS,.png,.PNG,.tif,.TIF,.jpg,.JPG,.jpeg,.JPEG}}

\usepackage[utf8]{inputenc}
\usepackage[english]{babel}



\usepackage{float}








\begin{document}

\title{The impact of angiotensin-converting enzyme inhibitors on lung cancer
and non-lung cancers compared with angiotensin II receptor blockers}



\author[1]{Leyi Wang}%
\author[1]{Tonghao Lei}%
\author[1]{Wenchang Zhang}%
\author[1]{Changjian He}%
\author[1]{Wence Shi}%
\author[1]{Da Zhang}%
\author[1]{Tengfei Liu}%
\author[1]{Zihan Zhao}%
\author[1]{Chunhua Ding}%
\affil[1]{Aerospace Center Hospital}%


\vspace{-1em}



  
  \date{May 28, 2024}


\begingroup
\let\center\flushleft
\let\endcenter\endflushleft
\maketitle
\endgroup





\selectlanguage{english}
\begin{abstract}
\emph{Aim:} Angiotensin-converting enzyme inhibitors (ACEIs) and
angiotensin II receptor blockers (ARBs) have been reported to manifest
controversial relationships with cancer, and recent focus concerning the
tumorigenic effect of ACEIs mainly falls on lung cancer. We compared
ACEIs with ARBs for their impact on the risk and prognosis of lung
cancer and non-lung cancers, respectively. \emph{Methods:} A
meta-analysis was performed to explore the impact of ACEIs on the risk
of lung cancer and non-lung cancers, while a systematic review was
performed to further analyze ACEIs' influence on the prognosis of lung
cancer. Terms concerning ACEIs and cancer were searched, and 10 cohort
studies were included for risk analysis, while 5 cohort studies were
included for analyzing the prognosis of lung cancer. \emph{Results:}
Initial pooled result revealed that ACEIs prescription is associated
with an observed increase on the risk of lung cancer (RR 1.28, 95\% CI
1.02-1.61), colorectal cancer (RR 1.46, 95\% CI 1.13-1.87) and hepatic
cancer (RR 2.00, 95\% CI 1.01-3.94) when compared with ARBs, but further
sensitivity analyses suggested the results unsolid, thus neither the
development of lung cancer nor non-lung cancers could be proved
associated with ACEIs prescription. However, systematic review suggested
that ACEIs prescription is associated with an improved lung cancer
prognosis. \emph{Conclusion:} There has been no adequate evidence to
demonstrate that ACEIs are associated with a higher incidence of lung
cancer or non-lung cancers, but an improved prognosis of lung cancer was
observed in patients taking ACEIs. Large-scale RCTs are needed and
underlying mechanisms need further exploration.%
\end{abstract}%



\sloppy


\textbf{Hosted file}

\verb`Manuscript.docx`  available at \url{https://authorea.com/users/652821/articles/660138-the-impact-of-angiotensin-converting-enzyme-inhibitors-on-lung-cancer-and-non-lung-cancers-compared-with-angiotensin-ii-receptor-blockers}\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/Figure-1/Figure-1}

\end{center}
\end{figure}\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/Figure-2/Figure-2}

\end{center}
\end{figure}\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/Figure-3/Figure-3}

\end{center}
\end{figure}

\selectlanguage{english}
\FloatBarrier
\end{document}

